Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Development and Evaluation of Nephroprotective Polyherbal Formulation against Methotrexate Induced Toxicity in Sprague Dawley Rat

    Arijit Chaudhuri1,2, Udichi Kataria1★, Subodh Kumar Dubey2, Neha Chopra2, Devendra Dhanorya2, Kamal Shah3, Nagendra Singh Chauhan4★ Corresponding author

    1. 1Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur, Rajasthan, INDIA.
    2. 2School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, INDIA.
    3. 3Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
    4. 4Drugs Testing Laboratory Avam Anusandhan Kendra ,Raipur Chhattisgarh, INDIA.

    CORRESPONDENCE

    Udichi Kataria

    Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur, Rajasthan, INDIA.

    udichi.gip@gmail.com

    Received: 19-08-2023; Revised: 12-09-2023; Accepted: 29-09-2023.

    Volume 16, Issue 1 · pp. 140–145 · PUBLISHED · DOI: 10.5530/pres.16.1.17

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Methotrexate (MTX) is one of the most broadly used anti-cancer derivative of aminopterin and it is a first folic acid antagonist. Adult cancer, various malignancies, multiple sclerosis, dermatomyositis, sarcoidosis, psoriasis, rheumatoid arthritis, and severe inflammatory disorders are all commonly treated with MTX. Medicinal plants and herbs contribute, wide range of treatment and prevention from several diseases. Herbal formulations mean dosage form consisting of one or more plants prepared herbs in selected quantities to cure mitigate diseases, by treatment, prevention and sometimes use as a supplement. Petrida foetidais used as traditionally diarrhea, stomach ache and nutritional supplement etc.Vitis vinifera, the fruit is used for dietary and the leaves and seeds are used as several herbal therapy. The current study had carried out to evaluate the nephroprotective activity of leaves and seed extracts of Petrida foetida and Vetis venifera. Nephroprotective activities of ethanolic and aqueous extracts of Petrida foetida and Vitis viniferaseeds were examined against methotrexate induced Kidney damage in Sprague Dawley Rats. Biochemical parameter evaluates like Urea, Creatinine, Uric acid, Blood urea nitrogen, total protein like albumin, globulin was analyzed. Petrida foetida and Vitis venifera seeds extract of exhibited significant (p<0.05) nephroprotective activity. Ethanolic seeds extract of Vitis viniferaand Petrida foetidamenifest moderate activity upon Methotrexate induced Rat models. Study outcome shows the traditional-ethno medicinal use of Methotrexate as a potential source of Nephroprotective activity.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Chaudhuri, A., Kataria, U., Dubey, S. K., Chopra, N., Dhanorya, D., Shah, K., & Chauhan, N. S. (). Development and Evaluation of Nephroprotective Polyherbal Formulation against Methotrexate Induced Toxicity in Sprague Dawley Rat. Pharmacognosy Research, 16(1), 140–145. https://doi.org/10.5530/pres.16.1.17