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    Hyperlipidemic Potential of Polyherbal Siddha Formulation D5 Chooranam

    Gaddam Dayanand Reddy1★, Rethinam Ganesan2, Manikantavinay Jayavaram1, Venkata Narasimhakumar G3, Bhavani Krishnamoorthy1, Shahana Ahamed1★ Corresponding author

    1. 1Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, INDIA.
    2. 2Department of Biochemistry, Siddha Central Research Institute, Chennai, Tamil Nadu, INDIA.
    3. 3Department of Pharmacology, Dr. Anjali Chatterjee Regional Research Institute for Homeopathy, Kolkata, West Bengal, INDIA.

    CORRESPONDENCE

    Gaddam Dayanand Reddy

    Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, INDIA.

    dayanandscri@gmail.com

    Received: 14-09-2023; Revised: 09-11-2023; Accepted: 10-12-2023.

    Volume 16, Issue 2 · pp. 376–383 · PUBLISHED · DOI: 10.5530/pres.16.2.47

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background:Hyperlipidemia is an important public health problem with increasing incidence and prevalence worldwide. D5 Chooranamis a synergetic Siddha polyherbal formulation designed by Central Council for Research in Siddha which is under patent process. Materials and Methods:In this study assessment of antihyperlipidemic activity of D5 Chooranamwas carried out using high fat diet-induced hyperlipidemic model. After 8 weeks of induction hyperlipidemia, the male Wistar rats were treated orally with 250 mg/kg, 500 mg/kg and 750 mg/kg of D5 Chooranamfor 6 weeks. Results:The results demonstrated significant hypolipidemic activity by lowering total cholesterol, Low Density Lipoprotein (LDL), Very Low-Density Lipoprotein (VLDL), and triglycerides and by increasing HDL levels compared to hyperlipidemic rats. Atorvastatin (10 mg/kg) was used as a positive control. The reduced AST and ALT levels showed its protective role against hepatic damage. Histopathological findings in rat liver supported the protective role of D5 Chooranamin HFD-induced fatty liver. No significant changes in the renal and cardiac markers provide evidence that D5 Chooranammay not possess serious side effects. Conclusion:Therefore, the study suggests that D5 Chooranamcould be effective in treating hyperlipidemia.

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      Reddy, G. D., Ganesan, R., Jayavaram, M., G, V. N., Krishnamoorthy, B., & Ahamed, S. (). Hyperlipidemic Potential of Polyherbal Siddha Formulation D5 Chooranam. Pharmacognosy Research, 16(2), 376–383. https://doi.org/10.5530/pres.16.2.47