Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Diuretic and natriuretic activity of two mistletoe species in rats

    Namita Jadhav1, C. R. Patil2, K. B. Chaudhari1, J. P. Wagh1, S. J. Surana1, R. B. Jadhav1★★ Corresponding author

    1. 1aBioecology Laboratory, Departments of Pharmacognosy
    2. 2Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur - 425 405, India

    CORRESPONDENCE

    R. B. Jadhav

    *Address for correspondence: Dr. R. B. Jadhav, Bioecology Laboratory, Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist. Dhule - 425 405, Maharashtra, India.

    ramjadhav123@yahoo.co.in

    Received: 23-11-2009; Revised: 12-02-2010; Accepted: 13-03-2010.

    Volume 2, Issue 1 · pp. 50–57 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.60576

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    In different cultural groups, the hemiparasitic plants of the families Loranthaceae and Viscaceae (mistletoes) are frequently used in the treatment of hypertension and/or as diuretic agents. However, it remains unclear as to what commonality makes them diuretic agents or a remedy for hypertension. In this article, the diuretic activity of methanol extracts of Viscum articulatum (VA) Burm. f. and Helicanthus elastica (HE) (Ders.) Dans. in rats is reported. The extracts were administered orally at doses of 100, 200 and 400 mg/kg to rats that had been fasted and deprived of water for 18 hours. Investigations were carried out for diuretic, saluretic and natriuretic effects. The polyphenolic and triterpenoid contents were determined quantitatively using chemical assays and high performance liquid chromatography (HPLC) analysis, respectively. The extracts of VA and HE demonstrated significant and dose-dependent diuretic activity in rats. It was found that while VA mimics the furosemide pattern, HE demonstrated a dose-dependent increase in diuresis, along with an increase in potassium-sparing effects. Phytochemical analysis revealed that polyphenolics and triterpenoids, such as oleanolic acid and lupeol, are the major phytochemicals involved. It was also found that in different combinations, these phytochemicals differed in the way they influenced the electrolyte excretion. A higher content of polyphenolics in association with lower triterpenoid content was found to favor potassium-sparing effects.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Jadhav, N., Patil, C. R., Chaudhari, K. B., Wagh, J. P., Surana, S. J., & Jadhav, R. B. (2010). Diuretic and natriuretic activity of two mistletoe species in rats. Pharmacognosy Research, 2(1), 50–57. https://doi.org/10.4103/0974-8490.60576