Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats

    Azadeh Sabetghadam1, Surash Ramanathan1, Sharif Mahsufi Mansor1★★ Corresponding author

    1. 1aCentre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

    CORRESPONDENCE

    Sharif Mahsufi Mansor

    *Address for correspondence: Dr. Sharif Mahsufi Mansor, Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

    smahsufi@usm.my

    Received: 10-02-2010; Revised: 03-06-2010; Accepted: 19-07-2010.

    Volume 2, Issue 3 · pp. 181–185 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.65514

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Mitragyna speciosa Korth is a medicinal plant indigenous to Thailand and Malaysia and has been known for its narcotic and coca-like effects. Many studies have been performed on the antinociceptive effect of the plant extracts of Thai origin; however, limited studies have been reported till date on M. speciosa extracts of Malaysian origin. Various concentrations of alkaloid (5–20 mg/kg), methanolic (50–200 mg/kg), and aqueous (100–400 mg/kg) extracts of Malaysian M. speciosa leaves were prepared and orally administered to nine groups of rats. Morphine (5 mg/kg, s.c.) and aspirin (300 mg/kg, p.o.) were used as control. Antagonism of the antinociceptive activity was evaluated by pretreatment with naloxone at a dose of 2 mg/kg (i.p.). Results showed that oral administration of the alkaloid (20 mg/kg), methanolic (200 mg/kg), and aqueous (400 mg/kg) extracts significantly prolonged the latency of nociceptive response compared with control groups in both hot plate and tail flick tests (P < 0.05). Antinociceptive action of the alkaloid (20 mg/kg), methanolic (200 mg/ kg), and aqueous (400 mg/kg) extracts was significantly blocked by naloxone. In conclusion, these results suggest the presence of antinociceptive effect in various extracts of Malaysian M. speciosa leaves. In addition, the antinociceptive effective doses vary depending on the type of solvents used for extraction.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Sabetghadam, A., Ramanathan, S., & Mansor, S. M. (2010). The evaluation of antinociceptive activity of alkaloid, methanolic, and aqueous extracts of Malaysian Mitragyna speciosa Korth leaves in rats. Pharmacognosy Research, 2(3), 181–185. https://doi.org/10.4103/0974-8490.65514