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    Cytotoxic essential oil from Annona sengalensis Pers. leaves

    A. L. Ahmed1★, S. E. M. Bassem2, Y. H. Mohamed3, M. W. Gamila2★ Corresponding author

    1. 1aDepartment of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia
    2. 2Department Pharmacognosy, National Research Centre Dokki, 12622 Giza, Egypt
    3. 3Department Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

    CORRESPONDENCE

    A. L. Ahmed

    *Address for correspondence: Dr. Ahmed Abdel-Lateff, Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

    ahmedabdellateff@yahoo.com

    Received: 30-01-2010; Revised: 05-02-2010; Accepted: 07-09-2010.

    Volume 2, Issue 4 · pp. 211–214 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.69105

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    The cytotoxicity against brine shrimp of the essential oil obtained from the leaves of Annona senegalensis Pers. (Annonaceae) was studied. The confirmation of this toxicity has been done by using selected tumor cell lines (A549, HT29, MCF 7, RPMI, and U251). The results showed that the total oil and its fractions have showed mild to moderate cytotoxicity in brine shrimp lethality bioassay with LC50 = 27.3 μg/ml, and against some human tumor cell lines. The total oil and its fractions were analyzed by gas chromatography/mass spectroscopy (GC/MS). Seventy three compounds were identified.

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      Ahmed, A. L., Bassem, S. E. M., Mohamed, Y. H., & Gamila, M. W. (2010). Cytotoxic essential oil from Annona sengalensis Pers. leaves. Pharmacognosy Research, 2(4), 211–214. https://doi.org/10.4103/0974-8490.69105