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    Effects of Gum acacia aqueous extract on the histology of the intestine and enzymes of both the intestine and the pancreas of albino rats treated with Meloxicam

    Ahmed M. A. Abd El-Mawla1,2★, Husam Eldien H. Osman3★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
    2. 2Department of Pharmacognosy, Faculty of Pharmacy, Taif University, Taif 21974, Saudi Arabia
    3. 3Department of Anatomy and Histology, Faculty of Medicine and Medical Sciences, Taif University, Taif 21974, Saudi Arabia

    CORRESPONDENCE

    Ahmed M. A. Abd El-Mawla

    *Address for correspondence: Dr. Ahmed M. A. Abd El-Mawla, Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

    ahmedpha2000@yahoo.com

    Revised: 02-12-2010.

    Volume 3, Issue 2 · pp. 114–121 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.81959

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage both in the upper and lower gastrointestinal tract, in addition to their undesirable side effects on the pancreas. Meloxicam like all NSAIDs has damaging effects on the gastrointestinal tract including perforations, ulcers and bleeding. Objective The present work describes the effects of Gum acacia aqueous extract on the histology of intestine and enzymes of both intestine and Pancreas of albino rats treated with Meloxicam. Materials and Methods This study was performed on four groups of equally weighed male rats, each group included ten animals; the first group was received a diet containing 0.2 mg/kg bw meloxicam per day; the second was given 1gm Gum acacia per day in its diet; the third was given meloxicam followed by gum in the same doses per day; while the fourth group (control rats) was placed on a normal diet and water. All rats were received their diet for a period of 21 days. Results A considerable protective effect of Gum acacia aqueous extract on the histology of intestine of albino rats treated with meloxicam was recorded. In addition, the study displayed a significant increase (P < 0.001) in the intestinal enzymes; lipase, amylase, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in the 1st and 3rd groups animals while these enzymes were significantly decreased (P < 0.001) in the 2nd group when compared with the 4th control group. Conclusion This study concluded that Gum acacia provides a protection and defense against the harmful effects of meloxicam therapy used as one of the novel anti-Cox-1 and Cox-2 NSAIDs.

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      El-Mawla, A. M. A. A., & Osman, H. E. H. (2011). Effects of Gum acacia aqueous extract on the histology of the intestine and enzymes of both the intestine and the pancreas of albino rats treated with Meloxicam. Pharmacognosy Research, 3(2), 114–121. https://doi.org/10.4103/0974-8490.81959