Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp

    Seif-Eldin N. Ayyad★, Saleh T. Ezmirly, Salim A. Basaif, Walied M. Alarif1, Adel F. Badria2, Farid A. Badria3★ Corresponding author

    1. 1Department of Chemistry, Faculty of Science, King Abdul Aziz University, P. O. 80203, Jeddah 21589, KSA
    2. 2Department of Marine Chemsitry, Faculty of Marine Sciences, King Abdulaziz University, Jeddah 21589, P O 80207, KSA
    3. 3Tissue Engineering Lab., Faculty of Dentistry, Alexandria University, Alexandria, Egypt
    4. 4Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

    CORRESPONDENCE

    Seif-Eldin N. Ayyad

    *Address for correspondence: Dr. Seif-Eldin N Ayyad, Faculty of Sciences, King Abdulaziz University, Jeddah-Saudi Arabia.

    snayyad2@yahoo.com

    Revised: 06-04-2011.

    Volume 3, Issue 3 · pp. 160–165 · PUBLISHED January 2011 · DOI: 10.4103/0974-8490.85000

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Macroalgae can be viewed as a potential antioxidant and anti-inflammatory sources owing to their capability of producing compounds for its protection from environmental factors such as heat, pollution, stress, oxygen concentration, and UV radiations. Objective To isolate major compounds which are mainly responsible for the pharmacological activity of brown alga under investigation, Sargassum sp. Materials and Methods Algal material was air dried, extracted with a mixture of organic solvents, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques, and two pure materials were tested for protection of DNA from damage, antioxidant, antitumor, and cytotoxicity. Results Four pure compounds were obtained, of which fucosterol (1) and fucoxanthin (4) were tested; it was found that fucoxanthin has strong antioxidant and cytotoxicity against breast cancer (MCF-7) with IC50= 11.5 μg/ml. Conclusion The naturally highly conjugated safe compound fucoxanthin could be used as antioxidant and as an antitumor compound.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Ayyad, S. N., Ezmirly, S. T., Basaif, S. A., Alarif, W. M., Badria, A. F., & Badria, F. A. (2011). Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp. Pharmacognosy Research, 3(3), 160–165. https://doi.org/10.4103/0974-8490.85000