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    Screening Togolese medicinal plants for few pharmacological properties

    Simplice D. Karou1,4★, Tchadjobo Tchacondo1, Micheline Agassounon Djikpo Tchibozo2, Kokou Anani1, Lassina Ouattara3, Jacques Simpore4, Comlan de Souza1★ Corresponding author

    1. 1Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM), Université de Lomé, BP 1515, Lomé, Togo
    2. 2Laboratoire de Microbiologie et des Technologies Alimentaires (LAMITA), Université d’Abomey-Calavi, Cotonou, Bénin
    3. 3Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles (CRSBAN), Université de Ouagadougou, BP 7021, Ouagadougou
    4. 4Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso

    CORRESPONDENCE

    Simplice D. Karou

    *Address for correspondence: Dr. Karou D. Simplice, Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA-UL), Université de Lomé, BP 1515, Lomé, Togo.

    simplicekarou@hotmail.com

    Revised: 29-07-2011.

    Volume 4, Issue 2 · pp. 116–122 · PUBLISHED October-December 2012 · DOI: 10.4103/0974-8490.94737

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Terminalia macroptera Guill. et Perr. (Combretaceae), Sida alba L. (Malvaceae), Prosopis africana Guill et Perr. Taub. (Mimosaceae), Bridelia ferruginea Benth. (Euphorbiaceae), and Vetiveria nigritana Stapf. (Asteraceae) are traditionally used in Togolese folk medicine to treat several diseases including microbial infections. Objective This study aimed to investigate the antimicrobial, antioxidant, and hemolytic properties of the crude extracts of the above-mentioned plants. Materials and Methods The antimicrobial and the antioxidant activities were assayed using the NCCLS microdilution method and the DPPH free radical scavenging, respectively. Human A+ red blood cells were used to perform the hemolytic assay. Phenolics were further quantified in the extracts using spectrophotometric methods. Results Minimal inhibitory concentrations in the range of 230–1800 µg/ml were recorded in the NCCLS broth microdilution for both bacterial and fungal strains with methanol extracts. The DPPH radical scavenging assay yielded interesting antioxidant activities of the extracts of P. africana and T. macroptera (IC50 values of 0.003 ± 0.00 µg/ml and 0.05 ± 0.03 µg/ml, respectively). These activities were positively correlated with the total phenolic contents and negatively correlated with the proanthocyanidin content of the extracts. The hemolytic assay revealed that great hemolysis occurred with the methanol extracts of T. macroptera, S. longepedunculata, and B. ferruginea. Conclusion These results support in part the use of the selected plants in the treatment of microbial infections. In addition, the plant showed an interesting antioxidant activity that could be useful in the management of oxidative stress.

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      Karou, S. D., Tchacondo, T., Tchibozo, M. A. D., Anani, K., Ouattara, L., Simpore, J., & Souza, C. D. (2012). Screening Togolese medicinal plants for few pharmacological properties. Pharmacognosy Research, 4(2), 116–122. https://doi.org/10.4103/0974-8490.94737