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    Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies

    Dan K. Afriyie1, George A. Asare2★, Kwasi Bugyei1, Isaac Asiedu-Gyekye1, Ben A. Gyan3, Samuel Adjei4, Phyllis Addo4, Archibald Sittie5, Alexander K. Nyarko6★ Corresponding author

    1. 1Department of Pharmacology, University of Ghana Medical School
    2. 2Department of Medical Laboratory Sciences, School of Allied Health Sciences
    3. 3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana
    4. 4Animal Experimentation Unit, NMIMR
    5. 5Center for Scientific Research into Plant Medicine, Mampong, Akuapim, Ghana
    6. 6Clinical Pathology, NMIMR

    CORRESPONDENCE

    George A. Asare

    *Address for correspondence: Dr George A. Asare, Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-bu, Accra, Ghana.

    gasare@chs.edu.gh

    Revised: 28-03-2012.

    Volume 5, Issue 1 · pp. 10–16 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.105640

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Croton membranaceus (CM) is used for benign prostate hyperplasia treatment. Objective Sub-chronic toxicity studies are non-existent and provided the basis for this study. Materials and Methods 90 days oral administration of a low dose (LD) (30 mg/kg b. wt.), medium dose (MD) (150 mg/kg b. wt.), and high dose (HD) (300 mg/kg b. wt.) CM aqueous root extract to 3 groups (n=6 each) of male Sprague-Dawley rats, alongside a control group, was undertaken. Urinalysis, hepato-renal function tests, lipid profile, cardiac enzymes, and routine hematology tests were performed. Results Triglyceride levels (C=1.05±0.19, LD=0.64±0.08, MD=0.55±0.04, HD=0.50±0.02 mmol/L) were significantly reduced (P<0.05). Very low density lipoprotein (C=0.48±0.09, LD=0.29±0.04, MD=0.25±0.02, HD=0.23±0.01 mmol/L) decreased significantly (P<0.05). Cardiac enzymes-creatinine kinase (C=568±172, LD=315±79, MD=441±209, HD=286±81 IU/L) decreased markedly (P<0.05) alongside lactate dehydrogenase (C=2675±875, LD=1667±1229, MD=1186±442, HD=855±239 IU/L) (P<0.05). Conclusion C. membranaceus aqueous root extract is non-toxic but demonstrates anti-atherogenic and anti-ischemic potentials.

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      Afriyie, D. K., Asare, G. A., Bugyei, K., Asiedu-Gyekye, I., Gyan, B. A., Adjei, S., Addo, P., Sittie, A., & Nyarko, A. K. (2013). Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research, 5(1), 10–16. https://doi.org/10.4103/0974-8490.105640