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    The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes

    Sanjib Bhattacharya1★, Moulisha Biswas2, Pallab K. Haldar3★ Corresponding author

    1. 1Division of Pharmacognosy, Bengal School of Technology (A College of Pharmacy), Hooghly
    2. 2Bengal Institute of Pharmaceutical Sciences, Nadia
    3. 3Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

    CORRESPONDENCE

    Sanjib Bhattacharya

    *Address for correspondence: Sanjib Bhattacharya, Pharmacognosy Division, Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly, West Bengal, India.

    sakkwai@yahoo.com

    Revised: 27-09-2012.

    Volume 5, Issue 2 · pp. 109–112 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.110540

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes. Objective The present study was aimed at the evaluation of in vitro antileishmanial effect of triterpenoid fraction from T. dioica root (CETD). Materials and Methods The antileishmanial activity of CETD was evaluated against Leishmania donovani (strain MHOM/IN/83/AG83) promastigotes by in vitro promastigote cell toxicity assay by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide). Potassium antimonyl tartrate was used as reference. Results Here, CETD markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner and demonstrated IC50 value of 18.75 mg/ml. The reference drug potassium antimonyl tartrate exhibited IC50 of 7.52 mg/ml. Conclusion From the present study it can be inferred that the triterpenoid fraction of T. dioica root exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.

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      Bhattacharya, S., Biswas, M., & Haldar, P. K. (2013). The triterpenoid fraction from Trichosanthes dioica root exhibits in vitro antileishmanial effect against Leishmania donovani promastigotes. Pharmacognosy Research, 5(2), 109–112. https://doi.org/10.4103/0974-8490.110540