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    Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents

    Samuel Adetunji Onasanwo1★, Benjamin Obukowho Emikpe2, Austin Azubuike Ajah1, Taiwo Olayemi Elufioye3★ Corresponding author

    1. 1Departments of Physiology, Faculty of Basic Medical Sciences, College of Medicine
    2. 2Veterinary Pathology, Faculty of Veterinary Medicine
    3. 3Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

    CORRESPONDENCE

    Samuel Adetunji Onasanwo

    *Address for correspondence: Dr. Samuel A. Onasanwo, Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria.

    samphil2002@yahoo.com

    Revised: 07-09-2012.

    Volume 5, Issue 3 · pp. 173–178 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.112423

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Materials and Methods Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. Results The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P £ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. Conclusion The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

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      Onasanwo, S. A., Emikpe, B. O., Ajah, A. A., & Elufioye, T. O. (2013). Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents. Pharmacognosy Research, 5(3), 173–178. https://doi.org/10.4103/0974-8490.112423