Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks

    Sophie Aboughe Angone1★, L. Mewono2, M. Boukandou Mounanga1, S. Medzegue3, H. F. Ella Mendene1, J.G. Mba Ndong1, J. F. Djoba Siawaya3, A. Souza4★ Corresponding author

    1. 1Pharmacopea and Traditional Medicine Institute, National Center of Technological and Scientific Research
    2. 2Medical Research unit Albert Schweitzer Hospital, Lambaréné
    3. 3National Laboratory of Public Health, Libreville
    4. 4National Institute of Agronomy and Biotechnology, Franceville, Gabon

    CORRESPONDENCE

    Sophie Aboughe Angone

    *Address for correspondence: Dr. Sophie Aboughe Angone, Pharmacopea and Traditional Medicine Institute, National Center of Technological and Scientific Research, Po. Box: 1156, Libreville, Gabon.

    sophie.aboughe@gmail.com

    Revised: 06-11-2012.

    Volume 5, Issue 3 · pp. 195–199 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.112427

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Chrysophyllum pruniforme of family sapotaceae is a plant used in traditional medicine in Gabon. Materials and Methods In this study, C. pruniforme barks were subjected to phytochemical screening and cytotoxicity investigations. Different concentrations of aqueous and total phenolic extract were tested on mice and on human erythrocytes. Results Phytochemical screening of C. pruniforme barks revealed the presence of flavonoids, saponins, and tannins, reducing sugars, polyphenols and traces of anthraquinones. When tested in vitro, aqueous and the phenolic extracts showed hemolytic activities on human erythrocytes with phenolic compounds being more cytotoxic than aqueous extracts. In vivo study of toxicity, allowed to determine the LD50 at 90 mg/kg for the doses of 50, 150 and 250 mg/kg of body weight. Conclusion These data indicate in one hand that C. pruniforme is rich in phenolic compounds and that the aqueous and total phenolic extracts could be considered as toxic for mice and maybe potentially toxic to humans in the other hand.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Angone, S. A., Mewono, L., Mounanga, M. B., Medzegue, S., Mendene, H. F. E., Ndong, J. M., Siawaya, J. F. D., & Souza, A. (2013). Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks. Pharmacognosy Research, 5(3), 195–199. https://doi.org/10.4103/0974-8490.112427