Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats

    Muhammad Afzal1,2, Imran Kazmi1★, Firoz Anwar1★★ Corresponding author

    1. 1Department of Pharmacology, Pacific University, Udaipur, Rajasthan
    2. 2Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India

    CORRESPONDENCE

    Imran Kazmi

    *Address for correspondence: Dr. Imran Kazmi, Siddhartha Institute of Pharmacy, Near IT Park, Dehradun – 248 001, Uttarakhand, India. ; Dr. Firoz Anwar, Prof. and Dean (Research and Academic), Siddhartha Institute of Pharmacy, Dobachi, Near IT Park, Dehradun – 248 001, Uttarakhand, India. E-mail: firoz_anwar2000@yahoo.com

    kazmiimran2005@gmail.com

    Revised: 06-10-2012.

    Volume 5, Issue 4 · pp. 247–253 · PUBLISHED January-March 2013 · DOI: 10.4103/0974-8490.118811

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Bryophyllum pinnatum Lam. used in folk medicine in tropical Africa, tropical America, India, China and Australia contains a wide range of active compounds, well known for their haemostatic and wound-healing properties. Objective The present study was designed to evaluate the effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine (DENA)-induced hepatic injury in rats. Material and Methods The aerial part of B. pinnatum aqueous and ethanolic extract was prepared in doses of 250 mg/kg and 500 mg/kg. Hepatic injury was induced by DENA. Acute toxicity was also carried out. Result Treatment with different doses of ethanolic extract of B. Pinnatum (250 mg/kg, p.o.) was not significantly able to treat the liver injury induced by DENA, but 500 mg/kg dose of ethanolic extract of B. Pinnatum protects the liver slightly. Treatment with different doses of aqueous extract of B. Pinnatum (250 and 500 mg/kg, p.o.) significantly (P*<0.05; P**<0.01 and P***<0.001) treated the liver injury induced by DENA. Conclusion It may be inferred from the present study that the hepatoprotective activities of the aqueous extract of B. Pinnatum leaves in DENA-induced hepatotoxicity may involve its antioxidant or oxidative free radical scavenging activities by alleviating lipid peroxidation through scavenging of free radicals, or by enhancing the activity of antioxidants.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Afzal, M., Kazmi, I., & Anwar, F. (2013). Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats. Pharmacognosy Research, 5(4), 247–253. https://doi.org/10.4103/0974-8490.118811