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    Article

    Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

    Seyed-Ebrahim Sajjadi1, Maryam Jamali2, Yalda Shokoohinia3,4★, Gisya Abdi5, Behzad Shahbazi3, Ali Fattahi6★ Corresponding author

    1. 1Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
    2. 2Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
    3. 3Novel Drug Delivery Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
    4. 4Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
    5. 5Department of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 67149
    6. 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    CORRESPONDENCE

    Yalda Shokoohinia

    *Address for correspondence: Dr. Yalda Shokoohinia, Novel Drug Delivery Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. ; yshokoohinia@gmail.com

    yshokoohinia@kums.ac.ir

    Revised: 09-02-2015.

    Volume 7, Issue 4 · pp. 322–328 · PUBLISHED October-December 2015 · DOI: 10.4103/0974-8490.158437

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background Ferulago macrocarpa is a plant used as flavoring agent and protectant in the food industry and as a folk medicinal plant in Iran with no available information on its chemical identity. Ferulago spp. showed to contain biologically terpenoids and coumarins. Objective The objective was to isolate and characterize terpenoids and coumarins from the acetone extract of F. macrocarpa fruits and to evaluate their antiproliferative effects on several cell lines. Materials and Methods A series of normal and reverse phase gravity and high-performance liquid chromatography analyses were used to purify constituents. Compounds 1–5 and 7 were evaluated for their cytotoxic effects on MCF-7, HT-29 and H-1299 cell lines. Results Six compounds including bornyl acetate (1), 1,10-di-epi-cubenol (2), stigmasterol (3) and three coumarins grandivittin (4), prantschimgin (5) and 4”-hydroxygrandivittin (7) along with mixtures of feruloyl derivatives (6a-6c) have been purified. Their structures were established by spectroscopic methods including nuclear magnetic resonance and MS analyses. Compound 2 showed moderate cytotoxicity effect with IC50 values of 5.0 and 6.7 mM on MCF-7 and HT-29, respectively. Conclusion 1,10-di-epi-Cubenol could be considered as a potential proliferation inhibitor of MCF-7 and HT-29 cell lines.

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      Sajjadi, S., Jamali, M., Shokoohinia, Y., Abdi, G., Shahbazi, B., & Fattahi, A. (2015). Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits. Pharmacognosy Research, 7(4), 322–328. https://doi.org/10.4103/0974-8490.158437