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    Ammi Visnaga in treatment of urolithiasis and hypertriglyceridemia

    Akshaya Srikanth Bhagavathula1, Ahed Jumah Mahmoud Al-Khatib2, Asim Ahmed Elnour3, Naama M. S. Al Kalbani5, Abdulla Shehab4★★ Corresponding author

    1. 1Department of Clinical Pharmacy, University of Gondar College of Medicine and Health Sciences, Gondar, Ethiopia
    2. 2Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    3. 3Departments of Pharmacology
    4. 4Internal Medicine, College of Medicine and Health Sciences, UAE University, Al Ain
    5. 5Department of Pharmacy, Tawam Hospital, Abu Dhabi, UAE

    CORRESPONDENCE

    Abdulla Shehab

    *Address for correspondence: Dr. Abdulla Shehab, Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.

    a.shehab@uaeu.ac.ae

    Revised: 22-11-2014.

    Volume 7, Issue 4 · pp. 397–400 · PUBLISHED October-December 2015 · DOI: 10.4103/0974-8490.167894

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Ammi visnaga is a widely distributed Ancient Egyptian medicinal plant used for treatment of several diseases including urolithiasis (kidney stones). The active chemical constituents’ khellin and visnagin obtained from the A. visnaga seeds have activity of antilithiogenic and pleiotropic. However, little is known about its activity on hypertriglyceridemia. The main aim of this review is to explore the use of A. visnaga in urolithiasis and to present a case of relevancy. We highlighted a case of a patient who has recurrent urethral stones and hypertriglyceridemia. The patient was treated with A. visnaga seeds, has recovered completely from ureteral stones and his high-density lipoprotein (HDL)-cholesterol low levels retained to normal after using of A. visnaga seeds for 10 days. The present case of A. visnaga seeds being local medicinal plant has shown the effect in treating urolithiasis with extended effect on raising HDL-cholesterol. These results may provide insights for in vitro studies for isolation of these biologically active compounds for potential in raising HDL-cholesterol. Whether or not the later effect can have clinical utility remains to be explored.

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      Bhagavathula, A. S., Al-Khatib, A. J. M., Elnour, A. A., Kalbani, N. M. S. A., & Shehab, A. (2015). Ammi Visnaga in treatment of urolithiasis and hypertriglyceridemia. Pharmacognosy Research, 7(4), 397–400. https://doi.org/10.4103/0974-8490.167894