Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy ResearchNOW IN
    Article

    Evaluation of anxiolytic activity of aqueous extract of Coriandrum sativum Linn. in mice: A preliminary experimental study

    K. Latha1, B. Rammohan1, B. P. V. Sunanda1, M. S. Uma Maheswari1, Surapaneni Krishna Mohan2★★ Corresponding author

    1. 1Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore
    2. 2Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Thandalam, Chennai, Tamil Nadu, India

    CORRESPONDENCE

    Surapaneni Krishna Mohan

    *Address for correspondence: Dr. Surapaneni Krishna Mohan, Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Saveetha Nagar, Thandalam, Chennai - 602 105, Tamil Nadu, India.

    krishnamohan.surapaneni@gmail.com

    Revised: 08-01-2015.

    Volume 7, Issue 5S · pp. S47–S51 · PUBLISHED 2015 · DOI: 10.4103/0974-8490.157996

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Objectives To evaluate the anxiolytic effect of Coriandrum sativum (CS) aqueous extract in mice. To compare the antianxiety activity of CS against standard drug diazepam (3 mg/ kg). Materials and Methods After obtaining Institutional Animal Ethics Committee approval, Swiss albino mice (18–25 g) of either sex were randomly divided into five groups of six animals each. Dried powder of CS leaves was boiled with distilled water, cooled, filtered, placed on a hotplate for complete evaporation, finally weighed and stored. The control group, test group, and standard drugs group received saline, CS extract (50, 100, and 200 mg/kg), diazepam (3 mg/kg), respectively, by oral feeding. The antianxiety effect was assessed by elevated plus maze (EPM) in mice. Results In EPM, it implied that CS 50 mg/ kg (Group III), 100 mg/kg (Group IV), and 200 mg/kg (Group V) significantly (P < 0.001) increases the number of entries in open arms compared to control. The time spent in open arms also increased in all the doses of CS extract significantly. Conclusion The current study demonstrates statistically significant dose-dependent antianxiety activity of CS leaves.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Latha, K., Rammohan, B., Sunanda, B. P. V., Maheswari, M. S. U., & Mohan, S. K. (2015). Evaluation of anxiolytic activity of aqueous extract of Coriandrum sativum Linn. in mice: A preliminary experimental study. Pharmacognosy Research, 7(5S), S47–S51. https://doi.org/10.4103/0974-8490.157996