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    Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)

    Ravi Shankara Birur Eshwarappa1,2,3, Yarappa Lakshmikantha Ramachandra3, Sundara Rajan Subaramaihha2, Sujan Ganapathy Pasura Subbaiah2, Richard Surendranath Austin4, Bhadrapura Lakkappa Dhananjaya5★★ Corresponding author

    1. 1Department of Chemistry, School of Graduate Studies
    2. 2Research Unit in Vrukshayurveda, A Division of Center for Advanced Studies in Biosciences, Jain University, Chamrajpete, Bengaluru
    3. 3Department of Studies and Research in Biotechnology, Kuvempu University, Shankarghatta
    4. 4Department of Biochemistry, University of Mysore, Mysore
    5. 5Department of Toxinology/Toxicology and Drug Discovery, Center for Emerging Technologies, Jain University, Kanakpura Taluk, Ramanagara, Karnataka, India

    CORRESPONDENCE

    Bhadrapura Lakkappa Dhananjaya

    Department of Toxinology/Toxicology and Drug Discovery, Center for Emerging Technologies Jain University, Karnataka, India.

    chandu_greeshma@rediffmail.com

    Volume 8, Issue 1 · pp. 78–84 · PUBLISHED Jan-Mar 2016 · DOI: 10.4103/0974-8490.171103

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Lipoxygenase (LOX) inhibitors are the promising therapeutic target for treating a wide spectrum of inflammatory-related diseases such as cancer, asthma, lymphoma, leukemia, and autoimmune disorders. In the present study, the photochemical constituents and the anti-LOX potential of leaf galls of Terminalia chebula are evaluated to exemplify its further potential development as medicine. Extracts of T. chebula galls were tested for anti-LOX activity using linoleic acid as substrate and lipoxidase as an enzyme and also the total content of polyphenols with phytochemical analysis of the extract were determined. The presence of highest total phenolic and flavonoid content of 141 ± 2.2 mg of gallic acid equivalent/g d.w and 125 ± 1.4 mg of quercetin equivalent/g d.w and maximal LOX inhibitory activity (52.67%) at 800 mg/mL concentrations were identified in the ethanolic extracts of leaf galls of T.chebula. The higher LOX inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. The results of this study confirm the folklore use of T. chebula leaves gall extracts as a natural anti-inflammatory agent and justify its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food, and nutraceuticals applications.

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      Eshwarappa, R. S. B., Ramachandra, Y. L., Subaramaihha, S. R., Subbaiah, S. G. P., Austin, R. S., & Dhananjaya, B. L. (2016). Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae). Pharmacognosy Research, 8(1), 78–84. https://doi.org/10.4103/0974-8490.171103