Modulating Effect of Hypnea musciformis (Red Seaweed) on Lipid Peroxidation, Antioxidants and Biotransforming Enzymes in 7,12‑Dimethylbenz (a) Anthracene Induced Mammary Carcinogenesis in Experimental Animals

ABSTRACT

Background:Breast cancer is the second most widespread diagnosed cancer and second leading cause of cancer death in women. Objective:The present work was carried out to evaluate the chemo preventive potential of Hypnea musciformis(ethanol extract) seaweed on oxidative stress markers, bio transforming enzymes, incidence of tumors, and pathological observation in 7,12-dimethylbenzanthracene (DMBA) exposed experimental mammary carcinogenesis. Materials and Methods:Female Sprague–Dawley rats were randomly divided into four groups. Rats in the group 1 served as control. Rats in the group 2 and 3 received a single subcutaneous injection of DMBA (25 mg/kg body weight (b.w)) in the mammary gland to develop mammary carcinoma. In addition, group 3 rats were orally administrated with 200 mg/kg between ofH. musciformis along with DMBA injection and group 4 rats received ethanolic extract of H. musciformisevery day orally (200 mg/kg b.w) throughout the experimental period of 16 weeks. Results:Our results revealed that treatment with H. musciformis ethanolic extract to DMBA treated rats significantly reduced the incidence of tumor and tumor volume as compared to DMBA alone treated rats. Moreover, our results showed imbalance in the activities/levels of lipid peroxidation by products, antioxidant enzymes, and bio transforming phase I and II enzymes in the circulation, liver and mammary tissues of DMBA treated rats which were significantly modulated to near normal on treatment with ethanolic extract ofH. musciformis. All these alterations were supported by histochemical findings. Conclusion: The results obtained from this study suggest that chemo preventive potential of H. musciformisethanol extract is probably due to their free radicals quenching effect and modulating potential of bio transforming enzymes during DMBA exposed experimental mammary carcinogenesis.

KEYWORDS

• Chemo prevention
• Hypnea musciformis
• Mammary carcinogenesis
• Oxidative stress
• Seaweeds

Showing references and in-text citations exactly as published.

• DOI10.4103/0974-8490.187085Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Res..

• Article · VOLUME 9, ISSUE 1Antihyperglycemic Activity of the Leaves from Annona cherimola Miller and Rutin on Alloxan-induced Diabetic RatsFernando Calzada, Jesús Iván Solares-Pascasio, RM Ordoñez-Razo, Claudia Velazquez, Elizabeth Barbosa, Normand García-Hernández, David Mendez-Luna, José Correa-Basurto · pp. 1–6Original ArticleSame type: Article
• Article · VOLUME 9, ISSUE 1Synergisms in Alpha‑glucosidase Inhibition and Antioxidant Activity of Camellia sinensis L. Kuntze and Eugenia uniflora L. Ethanolic ExtractsJuliana Vinholes, Márcia Vizzotto · pp. 101–107Original ArticleSame type: Article
• Article · VOLUME 9, ISSUE 1The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitro Release, and Antiproliferative Activity of Thymoquinone DrugSalwa Shaarani, Shahrul Sahul Hamid, Noor Haida Mohd Kaus · pp. 12–20Original ArticleSame type: Article
• Article · VOLUME 9, ISSUE 1Evaluation of Cholesterol‑lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar RatsGM Gururaja, Deepak Mundkinajeddu, A Senthil Kumar, Shekhar Michael Dethe, J Joshua Allan, Amit Agarwal · pp. 21–26Original ArticleSame type: Article