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    Insulin Plant (Costus pictus) Extract Restores Thyroid Hormone Levels in Experimental Hypothyroidism

    S Ashwini1, Zachariah Bobby1★, M. G. Sridhar1, C. C. Cleetus1★ Corresponding author

    1. 1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, INDIA.

    CORRESPONDENCE

    Zachariah Bobby

    Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, INDIA.

    zacbobby@yahoo.com

    Volume 9, Issue 1 · pp. 51–59 · PUBLISHED · DOI: 10.4103/0974-8490.199766

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: The aim of the present study was to investigate the preventive effect ofCostus pictusleaf extract in experimental hypothyroidism.Materials and Methods: Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and hypothyroid+extract (H+E). Rats in C group did not receive any intervention throughout the experimental period. The rats in the C+E and H+E groups received pretreatment with C. pictus leaf extract for 4 weeks. Subsequently, for the next 6 weeks, rats in the H group received 0.05% propylthiouracil in drinking water while C+E group received C. pictus leaf extract and H+E group received propyl thiouracil and C. pictusleaf extract. Results: Hypothyroid group rats exhibited dramatic increase in thyroid‑stimulating hormone (TSH) levels with concomitant depletion in the levels of thyroid hormones. Treatment with the extract resulted in remarkable improvement in thyroid profile. Extract produced 10.59‑fold increase in plasma free T3, 8.65‑fold increase in free T4, and 3.59‑fold decrease in TSH levels in H+E group in comparison with H group. Treatment with the extract ameliorated hypercholesterolemia, decreased levels of plasma C‑reactive protein and tumor necrosis factor alpha, suppressed tissue oxidative stress and prevented hepatic and renal damage caused due to thyroid hormone depletion in the H+E group. Pentacyclic triterpenes alpha and beta amyrins were identified and quantified in the extract. Conclusions:This is the first study to reveal that C. pictusextract has therapeutic potential to restore thyroid hormone levels and prevent the biochemical complications due to thyroid hormone insufficiency in the animal model of experimental hypothyroidism.

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      Ashwini, S., Bobby, Z., Sridhar, M. G., & Cleetus, C. C. (). Insulin Plant (Costus pictus) Extract Restores Thyroid Hormone Levels in Experimental Hypothyroidism. Pharmacognosy Research, 9(1), 51–59. https://doi.org/10.4103/0974-8490.199766