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    Pharmacognosy ResearchNOW IN
    Article

    Evaluation of anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413 capsule

    Sanjay Nipanikar1★, Sohan Chitlange2, Dheeraj Nagore3★ Corresponding author

    1. 1Head- R & D, R & D Center, Ari Healthcare Private Limited, Unit No. 401, International Biotech Park, BTS 2 Building, Chrysalis Enclave, 4th Floor, INDIA.
    2. 2MIDC Phase II, Hinjewadi, Pune, Maharashtra, India 2 Principal, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, Maharashtra, INDIA.
    3. 3Manager – Analytical Department, R & D Center, Ari Healthcare Private Limited, Unit No. 401, International Biotech Park, BTS 2 Building, Chrysalis Enclave, 4th Floor, Plot No – 2A, MIDC Phase II, Hinjewadi, Pune, Maharashtra, INDIA.

    CORRESPONDENCE

    Sanjay Nipanikar

    Head- R & D, R & D Center, Ari Healthcare Private Limited, Unit No. 401, International Biotech Park, BTS 2 Building, Chrysalis Enclave, 4th Floor, INDIA.

    sanjay.n@arihealthcare.in

    Volume 9, Issue 3 · pp. 273–276 · PUBLISHED · DOI: 10.4103/0974-8490.210328

    View on Pharmacogn. Res. original site ↗

    ABSTRACT

    Background: Conventional therapeutic agents used for treatment of Acne are associated with various adverse effects necessitating development of safe and effective alternative therapeutic agents. In this context, a polyherbal formulation AHPL/AYCAP/0413 was developed for treatment of Acne.Objectives: To evaluate Anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413. Material and Methods: 1) Anti-inflammatory activity: Anti-inflammatory activity of AHPL/AYCAP/0413 in comparison with Diclofenac was assessed in carrageenan induced rat Paw edema model. 2) Anti-microbial activity for P. acne: Propionibacterium acnes were incubated under anaerobic conditions. Aliquots of molten BHI with glucose agar were used as the agar base. Formulation and clindamycin (10 μg/ml) were introduced in to the Agar wells randomly. 3) Anti-microbial activity for Staphylococcus epidermidis and Staphylococcus aureus: Staphylococcus epidermidisand Staphylococcus aureuswere incubated under aerobic conditions at 37°C. TSB with glucose agar was used as the agar base. 0.5ml of formulation and clindamycin (10 μg/ml) were introduced in to the wells randomly. The antibacterial activity was evaluated by measuring zones of inhibition (in mm). Result: Significant reduction in rat paw edema (51% inhibition) was observed with formulation AHPL/AYCAP/0413 which was also comparable to that of Diclofenac (58% inhibition). Zone of inhibition for formulation was 18.33 mm, 19.20 mm and 26.30 mm for P. acnes, S. epidermidis and S. aureus respectively. This activity was also comparable to that of Clindamycin.Conclusion: AHPL/AYCAP/0413 capsule possesses significant Anti-inflammatory and Anti-microbial activities which further justifies its role in the management of Acne vulgaris.

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      Nipanikar, S., Chitlange, S., & Nagore, D. (). Evaluation of anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413 capsule. Pharmacognosy Research, 9(3), 273–276. https://doi.org/10.4103/0974-8490.210328