Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats
Priya Bisen1, Aman Chaturvedi1, Aditya Ganeshpurkar1★, Nazneen Dubey1★ Corresponding author
- 1Shri Ram Institute of Technology Pharmacy, Jabalpur, Madhya Pradesh, INDIA..
CORRESPONDENCE
Aditya Ganeshpurkar
Shri Ram Institute of Technology Pharmacy, Jabalpur, Madhya Pradesh, INDIA..
Received: 25-11-2019; Revised: 24-03-2020; Accepted: 20-05-2020.
Volume 10, Issue 1 · pp. 24–28 · PUBLISHED · DOI: 10.5530/fra.2020.1.5
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ABSTRACT
Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract ofAmaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.
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Bisen, P., Chaturvedi, A., Ganeshpurkar, A., & Dubey, N. (). Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats. Free Radicals and Antioxidants, 10(1), 24–28. https://doi.org/10.5530/fra.2020.1.5