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    Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study

    Mayank Kulshreshtha1★, Anuj Kumar Sharma1, Devender Pathak2, Pawan Pandey3, Varsha Snehi2, Karuna Shanker Shukla3, Akash Ved4, Arpita Singh5, Neeraj Verma6, Anita Sing7, Manjul Pratap Singh8★ Corresponding author

    1. 1Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
    2. 2Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
    3. 3Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.
    4. 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Lucknow, Uttar Pradesh, INDIA.
    5. 5Department of Pharmaceutics, Seth Vishambhar Nath Institute of Pharmacy, Barabanki, Lucknow, Uttar Pradesh, INDIA.
    6. 6Department of Pharmacology, Hygia College of Pharmacy, Lucknow, Uttar Pradesh, INDIA.
    7. 7Department of Pharmaceutics, Sundeep Pharmacy College, Ghaziabad, Uttar Pradesh, INDIA.
    8. 8Department of Pharmaceutics, ABESIT College of Pharmacy, Ghaziabad, Uttar Pradesh, INDIA.

    CORRESPONDENCE

    Mayank Kulshreshtha

    Department of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.

    professormayank@gmail.com

    Received: 14-03-2023; Revised: 24-03-2023; Accepted: 02-04-2023.

    Volume 13, Issue 1 · pp. 41–45 · PUBLISHED · DOI: 10.5530/fra.2023.1.7

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Background:Nowadays cardiac problems are the main cause of death. It includes coronary artery disease, angina pectoris (stable and unstable), congestive heart failure, etc. Objectives:The aim of this paper was to generate scientific data regarding in silico analysis of beta-sitosterol, coumaric acid, lupeol, qurecetin, and urosolic acid of Muscarinic (M2) receptor. Materials and Methods:The leaf powder was treated with different reagents and prepared with different extracts. The phytochemical screening was carried out by treated the extracts with different reagents for the presence of various metabolites. RCSB protein data bank had used for docking studies. Results: The phytochemical screening clearly revealed the presence of various metabolites like flavonoids, alkaloids, saponins, etc. In-silico analysis of beta-sitosterol, coumaric acid, lupeol, qurecetin, and urosolic acid had very good interactions with cholinergic receptor (M2). The obtained score is -7.96, -5.63, -6.7, -7.73, -5.82 for beta-sitosterol, coumaric acid, lupeol, quercetin, and urosolic acid, respectively, which lies in the standard scale. Conclusion: All these metabolites (compounds) are present in Quisqualis indica leaf extracts (aqueous and ethanolic) and found to be good cardio protective agents.

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      Kulshreshtha, M., Sharma, A. K., Pathak, D., Pandey, P., Snehi, V., Shukla, K. S., Ved, A., Singh, A., Verma, N., Sing, A., & Singh, M. P. (). Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study. Free Radicals and Antioxidants, 13(1), 41–45. https://doi.org/10.5530/fra.2023.1.7