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    Free Radicals and AntioxidantsNOW IN
    Communication

    Radical scavenging ability of glycyrrhizin

    Kimie Imai1★, Yushi Takagi1, Ayano Iwazaki1, Kunio Nakanishi1★ Corresponding author

    1. 1Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan.

    CORRESPONDENCE

    Kimie Imai

    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan.

    imai@pharm.setsunan.ac.jp

    Received: 06-04-2013; Revised: 18-04-2013; Accepted: 25-04-2013.

    Volume 3, Issue 1 · pp. 40–42 · PUBLISHED · DOI: 10.1016/j.fra.2013.04.003

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Glycyrrhizin (Gly), a major constituent of licorice root, has been used for the treatment of chronic liver diseases in Japan. Reports have been contradictory as to whether Gly scavenges hydroxyl radicals and superoxide anion radicals. We examined the radical scavenging abilities of Gly and glycyrrhezic acid (GA), an aglycon of Gly. Gly and GA did not scavenge hydroxyl radicals or superoxide anion radicals, but both scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, in contrast to previous reports. The scavenging abilities of Gly and GA might play a role in the treatment of chronic liver diseases.

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      Imai, K., Takagi, Y., Iwazaki, A., & Nakanishi, K. (). Radical scavenging ability of glycyrrhizin. Free Radicals and Antioxidants, 3(1), 40–42. https://doi.org/10.1016/j.fra.2013.04.003