Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Free Radicals and AntioxidantsNOW IN
    Article

    Effect of Cypermethrin Induced Antioxidant Enzymes Systems in Response to Melatonin Administration in Drosophila Melanogaster

    Selvaraj Vasuki1, Sengodan Karthi1, Muthugoundar Subramanian Shivakumar1★★ Corresponding author

    1. 1Department of Biotechnology, Molecular Entomology Laboratory, School of Biosciences, Periyar University, Salem-11, Tamil Nadu, INDIA.

    CORRESPONDENCE

    Muthugoundar Subramanian Shivakumar

    Department of Biotechnology, Molecular Entomology Laboratory, School of Biosciences, Periyar University, Salem-11, Tamil Nadu, INDIA.

    skentomol@gmail.com

    Volume 6, Issue 2 · pp. 167–172 · PUBLISHED · DOI: 10.5530/fra.2016.2.6

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Introduction:Melatonin, the main hormonal product of the pineal gland, has pleiotropic bioactivity that encompasses numerous endocrinological and behavioral processes. Melatonin and several of its metabolites function as free radical scavengers and broad-spectrum antioxidants. Due to their small size and amphiphilic nature they can easily reach all cellular compartments. The aim of the present study was to investigate the effect of melatonin on cypermethrin induced free radical damage in Drosophila melanogaster. Methods: The pro-or antioxidant enzyme activities of superoxide dismutase (SOD), glutathione–S-transferase (GST), lipid peroxidation (LPO), peroxidase (POX), catalase (CAT) and cytochrome P450 were assayed. Results:SOD and cytochrome P450 enzymes show significant increase in the melatonin+synthetic pyrethroid treated group, while GST shows significantly decreased activity in melatonin+synthetic pyrethroid group with respect to control. Lipid peroxidation activity was significantly increased in the synthetic pyrethroid group and also in melatonin+synthetic pyrethroid treated groups. Conclusion:In conclusion, melatonin administered the resulted in activation/increased expression of Cyt P450, GST and SOD titers, showing that melatonin in addition to being an antioxidant molecules, it also participates in eliciting other antioxidant systems in insects.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Vasuki, S., Karthi, S., & Shivakumar, M. S. (). Effect of Cypermethrin Induced Antioxidant Enzymes Systems in Response to Melatonin Administration in Drosophila Melanogaster. Free Radicals and Antioxidants, 6(2), 167–172. https://doi.org/10.5530/fra.2016.2.6