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    Free Radicals and AntioxidantsNOW IN
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    Antioxidant, Antibacterial Activities and Identification of Bioactive Compounds from Terminalia chebula Bark Extracts

    Alagesan Venkatesan1, Arumugam Kathirvel2, Shanmugam Prakash1, Venugopal Sujatha1★★ Corresponding author

    1. 1Phytochemistry Lab, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem-636 011, Tamil Nadu, INDIA..
    2. 2Department of Chemistry, K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode-637 215, Tamil Nadu, INDIA..

    CORRESPONDENCE

    Venugopal Sujatha

    Phytochemistry Lab, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem-636 011, Tamil Nadu, INDIA..

    chemsujatha888@gmail.com

    Volume 7, Issue 1 · pp. 43–49 · PUBLISHED · DOI: 10.5530/fra.2017.1.7

    View on Free Rad. Antiox. original site ↗

    ABSTRACT

    Background: Free radical induces numerous diseases by damaging biomolecules such as lipids, proteins, RNA and DNA. Several scientists reported that numerous plants and plant extracts have potent antioxidant activities to scavenge free radicals. The present study was aimed to screen phytoconstituents,in vitro antioxidant and antibacterial potential in various solvent extracts of Terminalia chebula bark.Methods: Phytochemical analysis, estimation of various metabolites, in vitro antioxidant and antibacterial activity were done by adopting standard protocols. Selected bioactive (acetone) extract of T. chebula was analyzed for their phytochemical profile by GC-MS analysis.Results: The results of preliminary phytochemical screening analysis revealed that presence of various phytochemicals like, alkaloids, flavonoids, glycosides, terpenoids, phenolics, saponins and carbohydrates in most of the tested extracts. Acetone extract possess significant high quantity of both primary and secondary metabolites when compared with other extracts. Remarkable free radicals scavenging potential was observed in acetone extract with lowest IC50 values on all tested radicals namely, DPPH. (IC50=144.77 μg/ml), NO. (IC50=149.46 μg/ml), .OH (IC50=121.18 μg/ml), O2 .- (IC50=159.41 μg/ml), Reducing power (IC50=35.85 μg/ml), Fe2+ ion chelating (IC50=137.56 μg/ml) and TBARS (IC50=201.96 μg/ml). Acetone extract expressed significant high antibacterial activity againstS. typhi (15 mm). The result of GC-MS analysis of acetone extract shows the presence of 32 major bioactive compounds, including various phenolic, sesquiterpene, flavonoid, triazine and gibberellin compounds. Conclusion: The present study suggested that T. chebula bark extract serves as a good source of phytochemicals, natural antioxidant and antibacterial agent.

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      Venkatesan, A., Kathirvel, A., Prakash, S., & Sujatha, V. (). Antioxidant, Antibacterial Activities and Identification of Bioactive Compounds from Terminalia chebula Bark Extracts. Free Radicals and Antioxidants, 7(1), 43–49. https://doi.org/10.5530/fra.2017.1.7