Curcumin Improves the Behavior and Memory in Mice by Modulating the Core Circadian Genes and Their Associated Micro-RNAs
Dhondup Namgyal1,2, Kumari Chandan2, Sher Ali3, Rachna Mehta3, Maryam Sarwat2★★ Corresponding author
- 1Amity Institute of Neuropsychology and Neuroscience, Amity University, India.
- 2Amity Institute of Pharmacy, Amity University, Noida, India.
- 3School of Basic Sciences and Research, Department of Life Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.
CORRESPONDENCE
Maryam Sarwat
Amity Institute of Pharmacy, Amity University, Noida - 201303, Uttar Pradesh, India.
Received: 01-06-2020; Revised: 16-07-2020; Accepted: 10-09-2020.
Volume 11, Issue 2 · pp. 44–52 · PUBLISHED 2020 · DOI: 10.4103/jpp.JPP_86_20
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ABSTRACT
Objective: To investigate the neuroprotective effects of curcumin in albino mice focusing on memory and behavior. Materials and Methods: Four groups of 7 mice each, different concentrations of curcumin were administered for 3 weeks in 3 groups and the remaining group was kept as control. The effect of curcumin on behavior and memory was studied using various tests. The expression of core circadian rhythm genes and micro RNAs were also studied. Results: Our results revealed that curcumin improves the mice’s behavior by regulating oxidative stress, hippocampal neurogenesis, and modulation of core circadian genes and their associated micro-RNA. Conclusion: This study shows that curcumin has a potential neuroprotective effect.
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Namgyal, D., Chandan, K., Ali, S., Mehta, R., & Sarwat, M. (2020). Curcumin Improves the Behavior and Memory in Mice by Modulating the Core Circadian Genes and Their Associated Micro-RNAs. Journal of Pharmacology and Pharmacotherapeutics, 11(2), 44–52. https://doi.org/10.4103/jpp.JPP_86_20