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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Potentially Inappropriate Medications in Indian Geriatric Patients Visiting Out-patient Departments of Tertiary Care Teaching Hospital

    Maulik M. Patel1, Andrew S. Mark1★, Varsha J. Patel1★ Corresponding author

    1. 1Department of Pharmacology, Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India.

    CORRESPONDENCE

    Andrew S. Mark

    Department of Pharmacology, Dr. M. K. Shah Medical College and Research Centre, Chandkheda, Ahmedabad - 382 424, Gujarat, India.

    drandrew81@gmail.com

    Received: 13-02-2020; Revised: 03-07-2020; Accepted: 21-07-2020.

    Volume 11, Issue 2 · pp. 53–58 · PUBLISHED 2020 · DOI: 10.4103/jpp.JPP_16_20

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Aim: To investigate the prevalence of potentially inappropriate medications (PIMs) identified by the American Geriatrics Society Beers 2019 criteria in geriatric patients in India. Materials and Methods: This cross-sectional study was conducted between October 2018 and October 2019 in the tertiary care teaching hospital of the Gujarat state, India. Patients of either sex attending outpatient departments of age 65 years and above were included. Data including age, gender, department, relevant laboratory investigations, prescribed drugs, dosages, and duration was recorded in the Case Record Form. PIMs identified as per 2019 Beers criteria and analyzed. The association between age, gender, polypharmacy and encounter of PIMs was analyzed. Results: A total of 306 patients were analyzed. Mean age of patients was 69.43 (standard deviation = 5.47) years and 185 (60.46%) were male. At least one PIM was prescribed in 46% (140) patients. Two or more PIMs were prescribed in 18.6% of patients. The most frequent PIMs independent of diagnosis and condition (Criteria 1) were first-generation antihistaminics 25.7%, skeletal muscle relaxants 21% and sulfonylureas (glimepiride) 17.4%. The most common drugs to be used with caution (Criterion 3) included tramadol 50.75%, diuretics 25.4%, and antipsychotics 13.5%. Patients who were on polypharmacy were at significantly high (P < 0.001) risk of PIM use with an adjusted odds ratio 4.864 (95% confidence interval: 2.95–8.03). Conclusion: Our study showed a high prevalence of PIMs use in Indian geriatric patients. There was an association between inappropriate medication use and polypharmacy.

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      Patel, M. M., Mark, A. S., & Patel, V. J. (2020). Potentially Inappropriate Medications in Indian Geriatric Patients Visiting Out-patient Departments of Tertiary Care Teaching Hospital. Journal of Pharmacology and Pharmacotherapeutics, 11(2), 53–58. https://doi.org/10.4103/jpp.JPP_16_20