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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats

    Marcelo Perim Baldo1★, Sérgio Lamêgo Rodrigues1, José Geraldo Mill1★ Corresponding author

    1. 1Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil.

    CORRESPONDENCE

    Marcelo Perim Baldo

    Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil.

    marcelobaldo@ymail.com

    Volume 3, Issue 1 · pp. 39–40 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.92508

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μg.kg-1) or vehicle. Thirty minutes later, animals were infarcted by coronary occlusion under artificial respiration. Electrocardiogram was monitored for 30 min to evaluate ventricular arrhythmias. Results: G-CSF treatment reduced the number of premature ventricular beats and the number and duration of ventricular tachycardia. The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 ± 2.4 vs. MI-GCSF: 5.4 ± 1 events; P < 0.05). However, total duration of ventricular fibrillation was not altered (MI-Cont: 84 ± 16 vs. MI-GCSF: 76 ± 13 sec). Conclusions: Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. However, the data suggest that G-CSF treatment may affect the spontaneous recovery from ventricular fibrillation. Acute G-CSF administration acts directly on cardiac electrophysiology, different from chronic treatment.

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      Baldo, M. P., Rodrigues, S. L., & Mill, J. G. (2012). Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats. Journal of Pharmacology and Pharmacotherapeutics, 3(1), 39–40. https://doi.org/10.4103/0976-500X.92508