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    Phcog.Net JOURNAL OF PHARMACOLOGY AND PHARMACOTHERAPEUTICS Volume 3 · Issue 1 2012 · pp. 1–305
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    Cover: Journal of Pharmacology and Pharmacotherapeutics

    Journal of Pharmacology and Pharmacotherapeutics

    Volume 3, Issue 1

    2012 · pp. 1–305 · 28 articles

    Volume
    3
    Issue
    1
    Published
    2012
    Pages
    1–305
    Articles
    28
    Sections
    10
    ISSN
    ISSN: Print - 0976-500X, Online - 0976-5018
    Journal
    J Pharmacol. Pharmacother.
    EditorialMini ReviewResearch PaperCommentaryResearch LettersCase ReportCorrespondenceNews and ViewsWeb WiseMolecules of the Millennium

    In this issue

    Editorial

    1. Forum Article

      Calling a spade a spade... why editors are uncomfortable to say it as it is

      Gitanjali B.

      pp. 1–3 · DOI: 10.4103/0976-500X.92490 · Published 2012

      Scientific writing calls scientists to say the truth, the whole truth and nothing but the truth. But in reality, try writing that and the chances are that your work will not get published;—at least not until it is said t…

    Mini Review

    1. Article

      Iptakalim: A novel multi-utility potassium channel opener

      (Kir6.1s) (Kir6.1s), regulatory sulphonylurea subunits (SUR).[3] IPT shows high selectivity for cardiac KATP (SUR2A/Kir6.2), vascular KATP (SUR2B/Kir6.1 or SUR6B/Kir6.2). Because

      pp. 12–14 · DOI: 10.4103/0976-500X.92495 · Published 2012

      Hypertension is a multifactorial disorder, and effective blood pressure control is not achieved in most individuals. According to the most recent report of the American Heart Association, for 2010, the estimated direct a…

    Research Paper

    1. Article

      A urinalysis-based study of buprenorphine and non-prescription opioid use among patients on buprenorphine maintenance

      Yatan Pal Singh Balhara, Raka Jain

      pp. 15–19 · DOI: 10.4103/0976-500X.92496 · Published 2012

      Objectives: To understand the pattern of use of opioid-substitution therapy (OST) and opioid abuse among patients on buprenorphine maintenance using urinalysis. Materials and Methods: The study was conducted at a tertiar…

    2. Article

      Secondary metabolites of Cynodon dactylon as an

      antagonist to angiotensin II type1 receptor: Novel in

      pp. 20–25 · DOI: 10.4103/0976-500X.92497 · Published 2012

      Objectives: To study the ability of the secondary metabolites of Cynodon dactylon to serve as an antagonist to angiotensin II type 1 receptor (AT1); activation of this receptor plays a vital role in diabetic retinopathy …

    3. Article

      Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells

      Christo Paul Preethy, Ramamoorthy Padmapriya, Vaiyapuri Subbarayan Periasamy, Anvarbatcha Riyasdeen, Suresh Srinag, Hanumanthappa Krishnamurthy, Ali Abdullah Alshatwi, Mohammad Abdulkader Akbarsha

      pp. 26–34 · DOI: 10.4103/0976-500X.92500 · Published 2012

      Objectives: To find the efficacy of serial extracts of Anisomeles malabarica in inhibiting proliferation of and inducing apoptosis in human cervical cancer cells, SiHa and ME 180, that are HPV 16-positive. Materials and …

    4. Article

      Analysis of hematinic formulations available in the Indian market

      B. N. Karelia, J. G. Buch

      pp. 35–38 · DOI: 10.4103/0976-500X.92504 · Published 2012

      Objectives: To analyze the hematinic formulations available in Indian market for their varieties of dosage forms, iron salts used, content of elemental iron, frequency of administration, additional nutrients, and cost. M…

    5. Article

      Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats

      Marcelo Perim Baldo, Sérgio Lamêgo Rodrigues, José Geraldo Mill

      pp. 39–40 · DOI: 10.4103/0976-500X.92508 · Published 2012

      Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 μg.kg-1) …

    6. Article

      Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

      Surender Singh, Vinod Nair, Yogendra K. Gupta

      pp. 43–47 · DOI: 10.4103/0976-500X.92512 · Published 2012

      Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materia…

    7. Article

      A randomized comparative study of safety and efficacy of immediate release glucosamine HCL and glucosamine HCL sustained release formulation in the treatment of knee osteoarthritis: A proof of concept study

      Chanda Kulkarni, Leena A., Lohit K., Devesh Mishra, Saji M. J.

      pp. 48–54 · DOI: 10.4103/0976-500X.92515 · Published 2012

      Objectives: To compare the safety and efficacy of glucosamine HCl- sustained release (GLU-SR) with that of Glucosamine HCl- immediate release (GLU-IR) in patients with knee osteoarthritis (OA). Materials and Methods: Thi…

    Commentary

    1. Article

      Phenylpropanolamine and the hemorrhagic stroke: A new search for the culprit

      Mostafa Yakoot

      pp. 4–6 · DOI: 10.4103/0976-500X.92491 · Published 2012

      Based primarily on the Final Report of the Hemorrhagic Stroke Project (HSP) released on May 2000,[3,4] the Food and Drug Administration (FDA) had concluded that there is an association between PPA and hemorrhagic stroke.…

    2. Article

      How full is our antihypertensives pipeline?

      Dilip Gude

      pp. 7–8 · DOI: 10.4103/0976-500X.92492 · Published 2012

      We have a plethora of new antihypertensives coming up with diverse mechanisms of action but if that would drastically change and better the management of hypertension remains to be seen. A review of the newer classes of …

    Research Letters

    1. Article

      Gender and racial bias in drug promotional material distributed by pharmaceutical companies

      Jaykaran, Preeti Yadav, N. D. Kantharia, Deepak Saxena

      pp. 55–56 · DOI: 10.4103/0976-500X.92517 · Published 2012

      Pharmaceutical industries promote their drugs with the intention to influence the prescription decision of health care provider / physicians and adopt various methods like distribution drug promotional materials to the h…

    2. Article

      Interns opinion on ‘bedside pharmacology clinics’ and its incorporation in undergraduate curriculum

      Pramod B. Akat, Vitthal B. Karande, Mangala B. Murthy, Shreyas R. Burute

      pp. 56–58 · DOI: 10.4103/0976-500X.92519 · Published 2012

      The rational prescribing of drugs is an essential skill of medical doctors. Clinical pharmacology plays an important role in the development of these skills by teaching clinical pharmacology and therapeutics to undergrad…

    3. Article

      Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems

      Dinesh Dhingra, Parul Joshi

      pp. 60–61 · DOI: 10.4103/0976-500X.92520 · Published 2012

      Depression is one of the major mental disorders affecting hundreds of millions of people all over the world. There is a constant need to identify newer antidepressants from plants. Benincasa hispida (Cucurbitaceae) fruit…

    4. Article

      Anticonvulsant activity of Erythrina mysorensis bark extract in an animal model of epilepsy

      T. S. Nagaraja, Riaz Mohamood, V. Krishna, B. S. Thippeswamy, V. P. Veerapur

      pp. 62–63 · DOI: 10.4103/0976-500X.92521 · Published 2012

      Epilepsy is a common neurological disorder characterized by paroxysmal dysrhythmia, seizure, with or without body convulsions and sensory or psychiatric phenomena. There are many mechanisms by which seizures can develop …

    5. Article

      Antidiabetic activity of stem bark of Bauhinia variegata in alloxan-induced hyperglycemic rats

      Parveen Kumar, Shailesh Baraiya, S. N. Gaidhani, M. D. Gupta, Manish M. Wanjari

      pp. 64–65 · DOI: 10.4103/0976-500X.92522 · Published 2012

      Diabetes mellitus, a chronic metabolic disorder of insulin deficiency or ineffectiveness, constitutes a global public health burden and predictions estimate that India, China, and United States will have the largest numb…

    6. Article

      Wound healing activity of Hemidesmus indicus formulation

      S. Ganesan, S. Parasuraman, S. Uma Maheswaran, N. Gnanasekar

      pp. 66–67 · DOI: 10.4103/0976-500X.92516 · Published 2012

      The discovery of drugs from medicinal plants provides new and important leads against various pharmacological targets including chronic diseases such as Alzheimer’s disease, malaria, and pain.[1] Hemidesmus indicus (Tami…

    Case Report

    1. Article

      Non-occlusive mesenteric ischemia and the role of cilostazol in its management

      K. A. Sudharshana Murthy, H. S. Kiran, Vijay Cheluvaraj, Abhijit Bhograj

      pp. 68–70 · DOI: 10.4103/0976-500X.92513 · Published 2012

      Bowel ischemia is a rare and potential life-threatening disorder. The reason for its rarity is the difficulty in its diagnosis. Vague and nonspecific clinical findings and limitations of diagnostic and treatment options …

    2. Article

      Diphtheria, pertussis (whooping cough), and tetanus vaccine induced recurrent seizures and acute encephalopathy in a pediatric patient: Possibly due to pertussis fraction

      Mahendra K. Patel, Tejas K. Patel, C. B. Tripathi

      pp. 71–73 · DOI: 10.4103/0976-500X.92514 · Published 2012

      A 5-month-old male patient developed recurrent seizures and acute encephalopathy possibly due to first dose of diphtheria, pertussis (whooping cough), and tetanus (DPT) vaccine used for routine immunization. Postreaction…

    Correspondence

    1. Article

      An adverse drug reaction clinic: Breathing fresh life into the pharmacovigilance programme

      Dick B. S. Brashier, Sushil Sharma

      pp. 74–75 · DOI: 10.4103/0976-500X.92501 · Published 2012

      After the launch of National Pharmacovigilance Programme in 2004[1], the Government of India came out with a revised programme called “Pharmacovigilance Programme of India (PvPI)” in 2010,[2] to streamline the drug safet…

    2. Article

      Assessing citations with Google Scholar: A new feature

      Mueen Ahmed K.

      pp. 75–76 · DOI: 10.4103/0976-500X.92502 · Published 2012

      Google Scholar is a well-known search engine, and allowed users to freely access scholarly articles. It indexes the full text of scholarly papers available in suitable publishing formats and disciplines.[1] Using Google …

    3. Article

      Prophylactic ocular hypotensives before Nd:YAG laser posterior capsulotomy

      Ashok K. Dubey

      pp. 79–80 · DOI: 10.4103/0976-500X.92505 · Published 2012

      The study groups under comparison seem to be similar at the start of the study and there is no apparent selection bias or probability of confounding, but randomization and blinding could have made the interpretation of r…

    4. Article

      Adverse drug reaction of oseltamivir in pediatric patients

      Somsri Wiwanitkit, Viroj Wiwanitkit

      pp. 81–81 · DOI: 10.4103/0976-500X.92507 · Published 2012

      I read the recent publication on the adverse drug reaction of oseltamivir in pediatric patients with a great interest.[1] Dalvi et al. concluded that “oseltamivir is well tolerated in Indian children with suspected or co…

    5. Article

      Belatacept: Good, but not good enough?

      Sreejith Parameswaran, R. P. Swaminathan

      pp. 82–83 · DOI: 10.4103/0976-500X.92510 · Published 2012

      Belatacept has brought about a ‘paradigm shift’ in the maintenance immunosuppression after solid organ transplantation, in that it is the first biologic agent approved for use for long-term maintenance immunosuppression …

    News and Views

    1. Article

      ‘Drug abuse’ of a different ‘wave’ length

      G. Sivagnanam

      pp. 85–6 · DOI: · Published 2012

      An alarming new stimulant, legal in many states...reports are emerging from hospitals around the country, as doctors scramble to figure out the best treatment for people high on bath salts. The drugs … have unusually dan…

    2. Article

      ‘Wiser’ are the ‘Winners’

      G. Sivagnanam

      pp. 85–6 · DOI: · Published 2012

      “Successful aging”, is defined as survival to age 70 years, not having a major chronic disease (such as coronary disease, cancer, stroke, and diabetes), and having no major cognitive impairment, physical impairment, or m…

    Web Wise

    1. Article

      The national centre for the replacement, refinement, and reduction of animals in research

      Jatinder Singh

      pp. 87–9 · DOI: · Published 2012

      The widespread use of animals has brought to the fore the issue of possible suffering endured by animals during experiments and how this outweighs the potential benefits of animal research.In most countries, strict regul…

    Molecules of the Millennium

    1. Article

      Belatacept: A worthy alternative to cyclosporine?

      George Melvin, Selvarajan Sandhiya, Kumaresan Subraja

      pp. 90–92 · DOI: 10.4103/0976-500X.92499 · Published 2012

      Renal transplant is the definitive therapy in patients with end-stage renal disease (ESRD) and offers the only solace for such patients who have no alternative other than frequent hemodialysis, a process which contribute…