Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems
Dinesh Dhingra1★, Parul Joshi1★ Corresponding author
- 1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.
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Dinesh Dhingra
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.
Volume 3, Issue 1 · pp. 60–61 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.92520
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ABSTRACT
Depression is one of the major mental disorders affecting hundreds of millions of people all over the world. There is a constant need to identify newer antidepressants from plants. Benincasa hispida (Cucurbitaceae) fruits were selected for evaluating its antidepressant potential in mice. There is only one study showing the antidepressant-like effect of the methanolic extract (0.6 and 1 g/kg administered three times and only once, respectively) of B. hispida fruits in mouse forced swim test (FST). The study showed the antidepressant-like effect of the methanolic extract in FST only and the mechanisms responsible for this activity have not been studied.
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Dhingra, D., & Joshi, P. (2012). Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems. Journal of Pharmacology and Pharmacotherapeutics, 3(1), 60–61. https://doi.org/10.4103/0976-500X.92520