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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Article

    Anticonvulsant activity of Erythrina mysorensis bark extract in an animal model of epilepsy

    T. S. Nagaraja1★, Riaz Mohamood2, V. Krishna3, B. S. Thippeswamy3, V. P. Veerapur3★ Corresponding author

    1. 1Department of Pharmaceutics, SJM College of Pharmacy, Chitradurga, India.
    2. 2Deptartment of Biotechnology & Bioinformatics, Kuvempu University, Shankarghatta, Shimogha, India.
    3. 3Department of Pharmacology, Siddaganga college of Pharmacy, Tumkur, Karnataka, India.

    CORRESPONDENCE

    T. S. Nagaraja

    Department of Pharmaceutics, SJM College of Pharmacy, Chitradurga, India.

    ts.nagaraja@rediffmail.com

    Volume 3, Issue 1 · pp. 62–63 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.92521

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Epilepsy is a common neurological disorder characterized by paroxysmal dysrhythmia, seizure, with or without body convulsions and sensory or psychiatric phenomena. There are many mechanisms by which seizures can develop in either normal or pathologic brains. Three common mechanisms include: (i) diminution of inhibitory mechanism (especially synaptic inhibition due to GABA), (ii) enhancement of the excitatory synaptic mechanism (especially those mediated by NMDA), and (iii) enhancement of endogenous neuronal burst firing (usually by enhancing voltage dependent calcium currents).[1] Erythrina mysorensis is a small tree with few or no prickles.[2] Literature survey reveals that there are no scientific reports regarding anti-epileptic activity of Erythrina mysorensis. Hence this study was undertaken to evaluate anti- epileptic activity of extract of Erythrina mysorensis bark using different in vivo models such as maximum electroshock (MES), pentylenetetrazole, and locomotor activity.

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      Nagaraja, T. S., Mohamood, R., Krishna, V., Thippeswamy, B. S., & Veerapur, V. P. (2012). Anticonvulsant activity of Erythrina mysorensis bark extract in an animal model of epilepsy. Journal of Pharmacology and Pharmacotherapeutics, 3(1), 62–63. https://doi.org/10.4103/0976-500X.92521