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    Journal of Pharmacology and PharmacotherapeuticsNOW IN
    Review

    Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis

    Jaykaran Charan1★, Jagdish P. Goyal2, Deepak Saxena3, Preeti Yadav1★ Corresponding author

    1. 1Departments of Pharmacology, College, Rajkot.
    2. 2P. D. U. Govt. Medical College, Rajkot.
    3. 3Department of Epidemiology, Indian Institute of Public Health, Ahmedabad, Gujarat, India Review Article.

    CORRESPONDENCE

    Jaykaran Charan

    Departments of Pharmacology, College, Rajkot.

    drjaykaran@yahoo.co.in

    Volume 3, Issue 4 · pp. 300–303 · PUBLISHED 2012 · DOI: 10.4103/0976-500X.103685

    View on J Pharmacol. Pharmacother. original site ↗

    ABSTRACT

    Objectives: To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials. Materials and Methods: Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2. Results: Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 – 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 – 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 – 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children’s group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 – 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 – 1.063) P = 0.075 respectively]. Conclusion: Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.

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      Charan, J., Goyal, J. P., Saxena, D., & Yadav, P. (2012). Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. Journal of Pharmacology and Pharmacotherapeutics, 3(4), 300–303. https://doi.org/10.4103/0976-500X.103685