Hypokalemia and rhabdomyolysis
Henrik Horwitz1★, Vidar A. Woeien1, Linda Wiuff Petersen2, Espen Jimenez‑Solem1★ Corresponding author
- 1Departments of Clinical Pharmacology, Hospital, University of Copenhagen, Denmark.
- 2Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
CORRESPONDENCE
Henrik Horwitz
Departments of Clinical Pharmacology, Hospital, University of Copenhagen, Denmark.
Received: 12-03-2014; Revised: 21-03-2014; Accepted: 11-09-2014.
Volume 6, Issue 2 · pp. 98–99 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.155488
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ABSTRACT
The adverse drug event manager of the Capital Region of Denmark received a report of a 65‑year‑old male with type II diabetes and long‑lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.
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Horwitz, H., Woeien, V. A., Petersen, L. W., & Jimenez‑Solem, E. (2015). Hypokalemia and rhabdomyolysis. Journal of Pharmacology and Pharmacotherapeutics, 6(2), 98–99. https://doi.org/10.4103/0976-500X.155488