Volume 17, Issue 4

2026 · pp. 477–633 · 16 articles

Volume: 17
Issue: 4
Published: 2026
Pages: 477–633
Articles: 16
Sections: 4
ISSN: ISSN: Print - 0976-500X, Online - 0976-5018
Journal: J Pharmacol. Pharmacother.

Review Article Original Research Article Case Report Short Communication

In this issue

Review Article

Review
Pharmacological Strategies in Cancer Immunotherapy: Advancing Immune Checkpoint Inhibitors, CAR-T Cell Therapies, and Cancer Vaccines
Vinay Kumar, Sadhana Misar Wajpeyi, Pankaj Yadav, Bhishmani Tarare
pp. 477–487 · DOI: 10.1177/0976500X251398611 · Published 2026
Background: Immunotherapy has wholly changed how cancer is treated by using the body’s immune system to eliminate cancer cells. Cancer vaccines, chimeric antigen receptor T-cell (CAR-T) treatments, and immune checkpoint …
Review
Innovative Pharmacotherapeutic Strategies for Autoimmune and Inflammatory Disorders: Advancing Precision Medicine in Disease Management
Nitika Senger, Sourabh Deshmukh
pp. 488–498 · DOI: 10.1177/0976500X251398610 · Published 2026
Background: Autoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis, are typified by immune dysregulation resulting in chronic inflammation and pr…
Review
Vestibular Stimulation as a Modulator of Metabolic Function: Implications for Diabetes Mellitus Management
Paneer Selvam Pandian, Selvaraj Vinoth Kumar, Anupam Biswas, Usha Kumari, Subramani Parasuraman
pp. 499–506 · DOI: 10.1177/0976500X261463370 · Published 2026
Metabolic disorders, including diabetes mellitus and obesity, continue to pose a major public health challenge. Diabetes is a disorder of glucose metabolism that can be associated with vestibular dysfunction. Traditional…
Review
Therapeutic Targets in Management of Polycystic Ovary Syndrome (PCOS): A Comprehensive Overview
Kapil Yadav, Rohit Malik, Nidhi Gehlawat, Namita Solanki, Syam Mohan, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Jobran M. Moshi, Ahmad Assiri, Saeed Alshahrani, Khaled A. Sahli, Hussam M. Shubaily, Marwa Qadri, Amani Khardali, Waseem Hassan
pp. 507–517 · DOI: 10.1177/0976500X261438924 · Published 2026
Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder affecting women of reproductive age, with a prevalence of about 10%. Hyperandrogenism, anovulation, polycystic ovarian morphology, and related hormonal and…

Original Research Article

Article
Exploring the Antioxidant and Anti-inflammatory Effects of Pumpkin and Olive Oil on Doxorubicin-induced Renal Toxicity in Rats
Mohammad Firoz Alam, Ali Mohammed Ali Hazazi, Mohamed Ahmed Al-Kasim, Abdulmajeed M. Jali, Ali Hanbashi, Saeed Alshahrani, Ayed A. Alshamrani, Wedad Mawkili, Maqbool Essa Oraiby, Sami Ibrahim, Ahmad Ali Daghriri, Syam Mohan, Yahya Mashour
pp. 518–529 · DOI: 10.1177/0976500X261417397 · Published 2026
Background: Doxorubicin (DOX), an anthracycline-based chemotherapeutic agent, has been widely used as a first-line treatment for several cancers, including hematological and solid tumors, but its clinical utility is limi…
Article
Effect of Water Pollution with Buprofezin on Freshwater African Adult Catfish (Clarias gariepinus)
Gobinath Ramachawolran, Kasi Marimuthu, Sreeramanan Subramaniam, Suresh V. Chinni
pp. 530–543 · DOI: 10.1177/0976500X261420581 · Published 2026
Background: Buprofezin, a thiadiazine insecticide globally recognized as a molting inhibitor, is widely used for controlling whitefly and other insect pests. Objectives: This study investigated the impacts of sub-lethal …
Article
A Novel Citrus medica Gel for the Treatment of Experimental Osteoarthritis: A Preclinical Study
Snehalakshmi Kavacheri Subramaniam, Umamaheswari Anbarasu, Bhuvaneswari Krishnamurthy, Manashaa Gnanaprakasam Poonguzhali
pp. 544–552 · DOI: 10.1177/0976500X261417415 · Published 2026
Background: Osteoarthritis (OA) is the most common form of arthritis affecting the elderly and obese population, and requires long-term medical management. Inflammatory pathways, possibly initiated by tissue damage and s…
Article
Machine Learning-driven QSAR and Docking Pipeline for Identification of Amyloid Beta-A4 Inhibitors in Alzheimer’s Disease
Sohith Reddy Korlagunta, Iniyan Muthamil Selvan, Sugapriya Dhanasekaran
pp. 553–561 · DOI: 10.1177/0976500X261417108 · Published 2026
Background/Objectives: Alzheimer’s disease (AD) is a long-term neurodegenerative condition that leads to the gradual deterioration of nerve cells. The goal of this study is to use computational drug discovery (CDD) techn…
Article
Medication Adherence Challenges : Factors Influencing Non-Adherence in Saudi Arabia
Seham M. Alsuhaymi, Khalid M. Almalki, Sarah I. Alghamdi, Shahad R. Kelantan, Rana M. Alnefaie, Eyad A. Alandijani, Atheer A. Jamal, Mohammed Shaikhomer, Asim M. Alshanberi, Reem B. Busaeed, Safaa M. Alsanosi, Yosra Z. Alhindi
pp. 562–570 · DOI: 10.1177/0976500X261417396 · Published 2026
Background: Chronic diseases present a significant health risk, and global medication adherence for these conditions remains insufficient. Understanding the factors that affect adherence is essential. Objectives: This st…
Article
Pharmacokinetic Study of Ceftriamidine Sodium for Injection in Chinese Healthy Volunteers
Zihan Liu, Ganmi Wang, Ning Chen, Jiarong Wu, Yueyuan You, Fei Qin, Huan Zhou
pp. 571–578 · DOI: 10.1177/0976500X261420055 · Published 2026
Background: MRSA and PRSP resistance has surged over 30 years, threatening clinical outcomes; China-developed cefathiamidine sodium, with enhanced pharmacokinetics, offers potent activity against these Gram-positive path…
Article
Updated Review of Customized Onboarding Strategies for Faculty in Competency-based Medical Education: Emerging Principles and Challenges
Prashant Kumar Singh, Shruti Singh, Veena Kumari Singh, Rajesh Kumar Meena
pp. 579–587 · DOI: 10.1177/0976500X261461084 · Published 2026
Competency-based medical education (CBME) marks a paradigm shift in medical training by prioritizing outcomes over timebased progression and focusing on clearly defined competencies aligned with societal needs. Faculty s…
Article
Dose–Response of Perineural Magnesium Sulphate in Ultrasound-guided Infraclavicular Brachial Plexus Block: A Randomised Double-blind Study Hemamalini Sridharan1 , Arun Parthasarathy1 , Diksha Dmello1 , Sachin Sogal P1,
Suvajit Podder, Savan Kumar Nagesh, Shweta Sinha, Deepali Shetty, Anula Dsouza
pp. 588–595 · DOI: 10.1177/0976500X261462416 · Published 2026
Background: Regional anaesthesia is widely preferred for upper limb surgeries, particularly those performed below the elbow; however, the limited duration of action of local anaesthetics remains a clinical challenge. The…
Article
l-Arginine Attenuates Brain Dysfunction in Heat-stress Rat Model via Modulating Nitric Oxide-dependent Pathway
Priya Jaswal, Rishabh Chaudhary, Jhilli Basu, Sowvik Bag, Sumeet Gupta, Seema Bansal
pp. 596–608 · DOI: 10.1177/0976500X261462646 · Published 2026
Background: Heat stress (HS) is the body’s inability to manage internal heat efficiently. It impairs endothelial function, causes oxidative stress, and disrupts nitric oxide (NO) signaling, highlighting the downstream ef…

Case Report

Article
Early Whole Bowel Irrigation to Treat Colchicine Overdose: A Brief Review of 30 Years of Decontamination Strategies
Mujtaba Mahmud, Matthew T. Stier, Jonathan D. Casey, Rebecca E. Bruccoleri, Joanna L. Stollings
pp. 609–616 · DOI: 10.1177/0976500X251409926 · Published 2026
A case of colchicine overdose of 27 mg, or 0.27 mg/kg (weight 99.8 kg), is reported to assess the potential symptoms seen with this type of toxicity and analyze a prospective treatment for successful outcomes. A 74-year-…
Article
Tuberculosis in APML with Persistent Pleural Thickening: A Case Report Chepsy Cherian Philip1, Bobby Abraham1, Sreehari Rajasekharakurup1, Aakash Chozakade1,
Paul Mathi Vathana Karunagaran, Edlin Domini Thakkekara
pp. 617–623 · DOI: 10.1177/0976500X261417406 · Published 2026
Background: Patients with acute promyelocytic leukemia (APML) undergoing induction therapy are severely immunocompromised and prone to opportunistic infections. Tuberculosis (TB), though less commonly considered, can com…

Short Communication

Communication
Redox Modulation in Down Syndrome by Platanus orientalis-derived Compounds Targeting the SOD1–GPx Axis
Hunar Jaiya, Nitya K., Sandhya Sundar, Ramya Ramadoss, Suganya Panneer Selvam
pp. 624–633 · DOI: 10.1177/0976500X261421671 · Published 2026
Background: Down syndrome (DS), caused by trisomy 21, is characterized by chronic oxidative stress resulting from overexpression of the superoxide dismutase 1 (SOD1) gene without a proportional increase in downstream ant…