Volume 17, Issue 3

Cutting-edge Pharmacological Innovations for Enhanced Post-surgical Wound Healing: Integrating Nanomedicine, Targeted Drug Delivery, and Natural Therapeutics

Shubham Patil, Sheetal Asutkar

pp. 321–331 · DOI: 10.1177/0976500X251367992 · Published 2026

Background: Surgical wound healing remains challenging in the clinical setting, bedeviled by infection, inflammation, and dysfunctional tissue regeneration. Present treatments rely on dressings and anti-biotics, whose bi…

Innovative Pharmacological Strategies Targeting Endothelial Dysfunction and Vascular Remodeling in Hypertension Management: A Narrative Review

Nitika Senger, Sourabh Deshmukh

pp. 332–341 · DOI: 10.1177/0976500X251398609 · Published 2026

Background: Hypertension is a worldwide health issue and an independent risk factor for cardiovascular disease. Endothelial dysfunction is an important mechanism for its pathogenesis, thus compromising vascular homeostas…

Cardiotoxicity Induced by Doxorubicin: Exploring Research Frontiers, Co-word Analysis, Trends, and Thematic Development

Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Saleh M. Abdullah, Jobran M. Moshi, Nizar A. Khamjan, Saeed Alshahrani, Khaled A. Sahli, Khloud H. Alsaadi, Marwa Qadri, Amani Khardali, Hussam M. Shubaily, Syam Mohan

pp. 342–354 · DOI: 10.1177/0976500X251411634 · Published 2026

Background: Doxorubicin (DX)-induced cardiotoxicity involves dose- and time-dependent myocardial injury driven by oxidative stress, mitochondrial dysfunction, and disrupted topoisomerase IIβ signaling, leading to progres…

Saffron Effectiveness to Alleviate Depression Symptoms and Cortisol Level of Medical Students with Mild–Moderate Depression: A Randomized Controlled Trial

Fhirastika Annisha Helvian, Saidah Syamsuddin, Erlyn Limoa, Irfan Idris, Indrawaty Suhuyanli, Ilhamuddin Ilhamuddin, Sonny Teddy Lisal

pp. 355–364 · DOI: 10.1177/0976500X251399510 · Published 2026

Background: Medical students experience a heightened risk of depression and necessitate effective, low-side-effect interventions. Objectives: This study evaluates the efficacy of saffron in decreasing salivary cortisol l…

Sociodemographic Factors and Medication Use Among Pulmonary Hypertension Patients at Teaching Hospital Jakarta

Diana Laila Ramatillah, Siti Halda, Fadhli Ramadhan, Baiq Retnanti Tiastiti, Kashif Ullah Khan, Sathvik Belagodu Sridhar, Michelle Darsono, Sylvia Rizky Prima, Nasser M. Aldekhail

pp. 365–373 · DOI: 10.1177/0976500X251400514 · Published 2026

Background: Pulmonary hypertension (PH) is a disorder of the pulmonary blood vessels that is often accompanied by other clinical conditions, which can lead to complications in cardiovascular and respiratory diseases. The…

Design of Patient-centric Hyperledger-based Blockchain Framework for Indian Healthcare Services

Namdev M. Sawant, Joanne Gomes

pp. 374–387 · DOI: 10.1177/0976500X251336871 · Published 2026

Background: The Indian healthcare system faces significant challenges, such as data fragmentation, lack of interoperability, and concerns about data security. The increasing digitization of healthcare requires a robust i…

A Comparative Study on the Effect of Placebo and Oral Clonidine as a Premedication on Onset and on the Duration of Spinal Anaesthesia with Hyperbaric Bupivacaine

Erra Shirish, P. Rajeshwar, Dinakar Mallem, Sravanthi Parusha, Apoorva Madem, Indira Pacharla, Vijay Kotra, Long Chiau Ming, Wen Han Chooi, Ching Siang Tan, Amal Suleiman, Sulaiman Sultan

pp. 388–395 · DOI: 10.1177/0976500X251353665 · Published 2026

Background: The utilisation of vasoconstrictors like clonidine with local anaesthetics during subarachnoid blockade is a well-established practice. Objectives: This study aims to compare the effects of oral clonidine pre…

Involvement of the Renal Kallikrein–Kinin System in the Diuretic Action of a Thiazide Using a Crossover Design in Rats: An Exploratory Study

Tomoe Fujita, Mariko Kamata, Yuji Kumagai, Masataka Majima

pp. 396–403 · DOI: 10.1177/0976500X251403738 · Published 2026

Background: We have reported that the renal kallikrein–kinin system is involved in the diuretic action of potassium or furosemide in rats. Objectives: The aim of this study was to investigate whether the renal kallikrein…

404–412 Noni (Morinda citrifolia Linn.) Fruit Extract Protects Against Non-precipitated Alcohol Withdrawal Symptoms in Mice

Asiya Begum, Jithendra Chimakurthy, Vijayapandi Pandy, Ramya Durgesam

pp. 404–412 · DOI: 10.1177/0976500X251398613 · Published 2026

Background: Noni (Morinda citrifolia Linn.) fruit has a long history of traditional use for treating several health conditions, including symptoms of major depression and anxiety. Objectives: This study focused on evalua…

Prospective Risk Management in the Process of Clinical Studies in the Republic of Serbia Nikola Rabrenović1 , Ivana Stević1 and Valentina Marinković1

pp. 413–421 · DOI: 10.1177/0976500X251404146 · Published 2026

Background: In Serbia, as well as worldwide, clinical trials are a significant and unavoidable part of the development of new medicines. There is limited research on prospective risk management in clinical trials in Serb…

Exploring the Therapeutic Axis of Antioxidant Alkaloids Against Sickle β-globin Mutation with Binding Site Engineering and Bioavailability

Dhruv Dhruv, Nitya K., Sandhya Sundar, Ramya Ramadoss, Suganya Panneer Selvam

pp. 422–429 · DOI: 10.1177/0976500X251406953 · Published 2026

Background: Sickle cell anemia is a monogenic hemoglobinopathy caused by a mutation in the β-globin gene (hemoglobin subunit beta, HBB), leading to the production of hemoglobin S (HbS). Under deoxygenated conditions, HbS…

Suzetrigine: A First-in-class NaV1.8 Inhibitor for Opioid-free Pain Management

Bala Ashwathy Radhakrishnan Malarvizhi, Indumathi Prabath, Sangeetha Raja, Jamuna Rani

pp. 430–440 · DOI: 10.1177/0976500X251412549 · Published 2026

Background: Opioids have been an integral part of pain management for many years. With the increasing global burden of opioid dependence, the development of non-opioid therapies provides a new framework for pain manageme…

Assessment Knowledge and Practice Among Pharmacy, Nursing, and Medical Students Regarding Hand Hygiene in Saudi Arabia Ahmad Jamal Mahrous1, Saeedah Hassan Mohammed Alfaifi2 , Bushra Fayed Alqurashi1 ,

Safa S. Almarzoky Abuhussain, Waleed Amasaib Ahmed, Hind Hamad Alrowais, Hanan Mohamed Moalim Abdullahi, Amir Aziz

pp. 441–447 · DOI: 10.1177/0976500X251409488 · Published 2026

Background: Hand hygiene is the key to prevent spread of infections in any health care setting. It is vital to understand and assess health care students knowledge and understanding towards hand hygiene so that effective…

Advances in Pharmacological Strategies for Brain Tumors: Molecular Insights and Therapeutic Innovations

Riya Karn, Anjali Kajal, Nidhi Gehlawat, Rohit Malik, Ganesh Narayan Sharma, Abdullah Abdu Hommdi, Mahdi Dafer Koriri, Ameer Alameer, Mohammed Ahmed Yahya Hassani, Abdullah Idris Qadh, Abdullah Mohammed Farasani, Jobran M. Moshi, Edrous Alamer, Nizar A. Khamjan, Ali A. Alqahtani, Syam Mohan

pp. 448–462 · DOI: 10.1177/0976500X251403645 · Published 2026

Background: Cancer is a complex condition defined by the uncontrolled growth and proliferation of cells. Brain neoplasms, both primary and secondary, present a rising global health burden. Newer classification integrates…

Comparative Evaluation of Peyton’s Four-step Approach and Conventional Teaching Methods for Injection Techniques: A Prospective, Interventional Crossover Study

Rushika Modi, Mira Desai, Aparajita Shukla, Chetan Parikh, Punit Patel, Jwalantkumar Joshi

pp. 463–470 · DOI: 10.1177/0976500X261417403 · Published 2026

Background: Traditional teaching methods can pose challenges for learners, particularly when it comes to applying theoretical knowledge in practical settings. In contrast, Peyton’s four-step approach provides a structure…