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    Article

    In vivo anti‑fatigue activity of sufu with fortification of isoflavones

    Yunxian Liu1★, Yun Zhou1★, Satoru Nirasawa2, Eizo Tatsumi2, Yongqiang Cheng1, Lite Li1★ Corresponding author

    1. 1Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China.
    2. 2Japan International Research Center for Agricultural Sciences, Tsukuba, 305‑8686, Japan.

    CORRESPONDENCE

    Yunxian Liu

    Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China.

    chengyq@cau.edu.cn

    Received: 23-02-2013; Revised: 29-03-2013.

    Volume 10, Issue 39 · pp. 367–373 · PUBLISHED 24 July 2014 · DOI: 10.4103/0973-1296.137380

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Sufu is a traditional Chinese fermented soybean food. Isoflavones are abundant in soybean and products incorporated with isoflavones exert many health benefits. The aim of this study was to investigate anti‑fatigue effect of sufu fortified with isoflavones. Materials and Methods: In vivo anti‑fatigue activity of sufu with fortification of isoflavones (IF) was investigated in this study via exhaustive swimming test using ICR mice and determination of biochemical parameters. Factors relating to fatigue, including hepatic glycogen, blood lactic acid (BLA), blood urea nitrogen (BUN) were determined. The isoflavone composition in the IF sufu was also determined to explore the anti‑fatigue activity of isoflavones. Results: During fermentation, isoflavone glucosides were converted into aglycones and both sufu with and without fortification of IF prolonged the exhaustive swimming time of ICR mice. Intake of sufu also increased the hepatic glycogen content, while it decreased the levels of both the blood lactic acid (BLA) and blood urea nitrogen (BUN) content. A dose‑response relationship was observed in both exhaustive swimming and BLA clearance test, with medium dose (1%) fortification of IF revealing the highest activity. Conclusion: IF sufu could possess high anti‑fatigue activity.

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      Liu, Y., Zhou, Y., Nirasawa, S., Tatsumi, E., Cheng, Y., & Li, L. (2014). In vivo anti‑fatigue activity of sufu with fortification of isoflavones. Pharmacognosy Magazine, 10(39), 367–373. https://doi.org/10.4103/0973-1296.137380