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    Effects of fermented Cordyceps sinensis on oxidative stress in doxorubicin treated rats

    Rong Wu1, Jian‑Ping Gao1★, Hui‑Lin Wang1, Yan Gao1, Qian Wu1, Xiao‑Hua Cui1★ Corresponding author

    1. 1Department of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, NO. 1200 Cailun Road, Shanghai, 201203, China.

    CORRESPONDENCE

    Jian‑Ping Gao

    Department of Pharmacology, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, NO. 1200 Cailun Road, Shanghai, 201203, China.

    zydgjp@aliyun.com

    Received: 08-12-2014; Revised: 16-01-2015.

    Volume 11, Issue 44 · pp. 724–731 · PUBLISHED 16 September 2015 · DOI: 10.4103/0973-1296.165562

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Cordyceps sinensis (CS) is one of the rare traditional Chinese herbs, only a very limited amount of natural CS is produced. Fermented CS, as a substitute for natural CS, is widely used in the field of supplementary medical treatment and health products. Its antagonistic effect on oxidative stress (OS) in vivo has not been investigated. Objective: Our aim was to investigate the antagonistic effect of fermented CS on OS in doxorubicin (DOX) treated rats and to compare the anti‑OS effects in heart and liver tissues. Materials and Methods: OS rats were induced by tail‑intravenous injection of DOX (total of 7.5 mg/kg), and then administered intragastrically with fermented CS (1.5 g/kg) for 4 weeks. At the end of the experiment, heart, liver and serum samples were taken for and biochemical analyses. Results: Fermented CS significantly increased the activities of glutathione peroxidase and catalase and the scavenging activity of O2 − in serum, and the total superoxide dismutase activity in cardiac tissue; reduced the malondialdehyde content in liver and cardiac tissues. Conclusion: Fermented CS can inhibit DOX‑induced OS reactions, and the anti‑OS effects have high selectivity to heart and liver, especially to heart. Thus, fermented CS may be a candidate used for the prevention against various cardiac diseases induced by OS.

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      Wu, R., Gao, J., Wang, H., Gao, Y., Wu, Q., & Cui, X. (2015). Effects of fermented Cordyceps sinensis on oxidative stress in doxorubicin treated rats. Pharmacognosy Magazine, 11(44), 724–731. https://doi.org/10.4103/0973-1296.165562