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    Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia‑reperfusion in mice

    Xiao‑Ping Huang2,3,4, Huang Ding4, Bei Wang3, Yong‑Yuan Qiu3, Ying‑Hong Tang4, Rong Zeng3, Chang‑Qing Deng2,3,4★★ Corresponding author

    1. 1Molecular Pathology Laboratory, Hunan University of Chinese Medicine, China.
    2. 2Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio‑Cerebral Diseases, China.
    3. 3Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques, Changsha, Hunan Province, People’s Republic of, China.

    CORRESPONDENCE

    Chang‑Qing Deng

    Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio‑Cerebral Diseases, China.

    dchangq@ sohu.com

    Received: 22-05-2014; Revised: 16-01-2015.

    Volume 11, Issue 44 · pp. 732–739 · PUBLISHED 16 September 2015 · DOI: 10.4103/0973-1296.165572

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Astragalus and Panax notoginseng are traditional Chinese medicines used for the treatments of cardio‑cerebrovascular ischemic diseases, astragaloside IV (AST IV) and ginsenoside Rg1 (Rg1), ginsenoside Rb1 (Rb1), notoginsenoside R1 (R1) are their active components. Objective: The purpose of this work was to investigate the effect of AST IV combined with Rg1, Rb1, R1 on energy metabolism in brain tissues after cerebral ischemia‑reperfusion in mice. Materials and Methods: C57BL/6 mice were randomly divided into 11 groups, treated for 3 days. At 1 h after the last administration, the model of cerebral ischemia‑reperfusion injury was established, and brain tissues were detected. Results: All drugs increased the contents of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and the level of total adenine nucleotides (TAN), the combinations increased energy charge (EC), the effects of four active components combination were better. The phosphorylation of AMP‑activated protein kinaseα1/2 (p‑AMPKα1/2) was increased in AST IV, R1, four active components combination, AST IV + Rg1 and AST IV + R1 groups, the increased effect of four active components combination was greater than that of the active components alone and AST IV + Rb1. All drugs increased glucose transporter 3 (GLUT3) mRNA and protein, and the increases of four active components combination were more obvious than those of the active components alone or some two active components combinations. Conclusion: Four active components combination of Astragalus and P. notoginseng have the potentiation on improving of energy metabolism, the mechanism underlying might be associated with promoting the activation of AMPKα1/2, enhancing the expression of GLUT3, thus mediating glucose into nerve cells, increasing the supply and intake of glucose.

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      Huang, X., Ding, H., Wang, B., Qiu, Y., Tang, Y., Zeng, R., & Deng, C. (2015). Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia‑reperfusion in mice. Pharmacognosy Magazine, 11(44), 732–739. https://doi.org/10.4103/0973-1296.165572