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    The isolation, Characterization and Preclinical Studies of Metal Complex of Thespesia populnea for the Potential Peroxisome Proliferator‑activated Receptors‑γ Agonist Activity

    Mohini Ashok Phanse1★, Manohar Janardhan Patil2, Konde Abbulu3★ Corresponding author

    1. 1Department of Pharmacognosy, Modern College of Pharmacy, Nigdi, India.
    2. 2Department of Pharmacognosy, Maratha Mitramandal College of Pharmacy, Kalewadi, Pune, Maharashtra, India.
    3. 3Department of Pharmaceutics, Mallareddy Institute of Pharmaceutical Sciences, Hyderabad, Telangana, India.

    CORRESPONDENCE

    Mohini Ashok Phanse

    Department of Pharmacognosy, Modern College of Pharmacy, Nigdi, India.

    phanse_mohini@yahoo.co.in

    Volume 11, Issue 44s2 · pp. 434–438 · PUBLISHED 2015 · DOI: 10.4103/0973-1296.168984

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Diabetes mellitus is an international public health problem since ancient days. The condition is predominantly more severe in developing countries like India where, life is more sedentary due to the even changing lifestyles in this fast‑paced global scenario. Thespesia populnea is widely used in the ayurvedic system of medicine for treatment of diabetes mellitus in India for years. The aim of this work is to explore the anti‑diabetic activity of the isolated compound. Materials and Methods: The sesquiterpene isolated from hexane fraction of bark of T. populnea modified synthetically then identified by using analytical techniques such as electron paramagnetic resonance spectra for confirmation and the anti‑diabetic activity was evaluated by anti‑hyperglycemic, hypoglycemic potential. Result: In the present work, we have studied the anti‑hyperglycemic and hypoglycemic activity of the vanadium complex in glucose loaded and normal animals were shown significantly decreased in plasma blood glucose level. The results derived from preclinical studies confirm the potential of new sesquiterpene. Conclusion: The findings could provide evidence regarding the anti‑diabetic potential of T. populnea by lowering blood glucose level.

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      Phanse, M. A., Patil, M. J., & Abbulu, K. (2015). The isolation, Characterization and Preclinical Studies of Metal Complex of Thespesia populnea for the Potential Peroxisome Proliferator‑activated Receptors‑γ Agonist Activity. Pharmacognosy Magazine, 11(44s2), 434–438. https://doi.org/10.4103/0973-1296.168984