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    Article

    Inhibitory Effect of Spirulina maxima on the Azoxymethane‑ induced Aberrant Colon Crypts and Oxidative Damage in Mice

    Isela Álvarez‑González1★, Víctor Islas‑Islas1, Germán Chamorro‑Cevallos2, Juan Pablo Barrios2, Norma Paniagua3, Verónica R. Vásquez-Garzón4,6, Saúl Villa‑Treviño4, Osiris-Madrigal-Santillán Osiris-Madrigal-Santillán5, José Antonio Morales-González1★ Corresponding author

    1. 1Eduardo Madrigal‑Bujaidar Department of Morphology, Genetics Laboratory, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738.
    2. 2Department of Pharmacy, Preclinical Toxicology, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738.
    3. 3Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738.
    4. 4Department of Cellular Biology, Center for Research and Advanced Studies, National Polytechnic Institute, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, D.F. 07360.
    5. 5Department of Conservation Medicine, Superior School of Medicine, National Polytechnic Institute, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, D. F. 11340.
    6. 6Cathedra-CONACYT, Faculty of Medicine and Surgery, Autonomous University “Benito Juárez” of Oaxaca, Av. Universidad s/n, Exhacienda de Cinco Señores, Oaxaca de Juárez, 68120. México.

    CORRESPONDENCE

    Isela Álvarez‑González

    Eduardo Madrigal‑Bujaidar Department of Morphology, Genetics Laboratory, National School of Biological Sciences, National Polytechnic Institute, Av. Wilfredo Massieu s/n. Lindavista, D. F. 07738.

    eduardo.madrigal@lycos.com

    Volume 11, Issue 44s3 · pp. 619–624 · PUBLISHED 2015 · DOI: 10.4103/0973-1296.172973

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Spirulina maxima (Sm) is a cyanobacterium well known because of its high nutritive value, as well as its anti‑inflammatory, anti‑hyperlipidemic, antioxidant, and anti‑genotoxic activities. Objective: To determine the capacity of Sm to inhibit the induction of aberrant colon crypts (AC), as well as the level of lipid peroxidation and DNA oxidative damage in mice treated with azoxymethane (AOM). Materials and Methods: Sm (100, 400, and 800 mg/kg) was daily administered to animals by the oral route during 4 weeks, while AOM (10 mg/kg) was intraperitoneally injected to mice twice in weeks 2 and 3 of the assay. We also included a control group of mice orally administered with distilled water along the assay, as well as other group orally administered with the high dose of Sm. Results: A significant decrease in the number of AC with the three tested doses of Sm, with a mean protection of 51.6% respect to the damage induced by AOM. Also, with the three doses of the alga, we found a reduction in the level of lipoperoxidation, as well as in regard to the percentage of the DNA adduct 8‑hydroxy‑2’‑deoxyguanosine. Conclusion: Sm possesses anti‑precarcinogenic potential in vivo, as well as capacity to reduce the oxidative damage induced by AOM.

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      Álvarez‑González, I., Islas‑Islas, V., Chamorro‑Cevallos, G., Barrios, J. P., Paniagua, N., Vásquez-Garzón, V. R., Villa‑Treviño, S., Osiris-Madrigal-Santillán, O., & Morales-González, J. A. (2015). Inhibitory Effect of Spirulina maxima on the Azoxymethane‑ induced Aberrant Colon Crypts and Oxidative Damage in Mice. Pharmacognosy Magazine, 11(44s3), 619–624. https://doi.org/10.4103/0973-1296.172973