Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum

    Ya Nan Sun1, Wei Li2, Seok Bean Song3, Xi Tao Yan4, Seo Young Yang4, Young Ho Kim4★★ Corresponding author

    1. 1College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
    2. 2School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea.
    3. 3Gyeongbuk Institute for Bio-industry, Andong City, Gyeongbuk 760-380, Korea.
    4. 4College of Pharmacy, Korea University, Sejong 339-700, Korea.

    CORRESPONDENCE

    Young Ho Kim

    College of Pharmacy, Korea University, Sejong 339-700, Korea.

    yhk@cnu.ac.kr

    Volume 12, Issue 45 · pp. 31–5 · PUBLISHED 2016 · DOI: 10.4103/0973-1296.176019

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Polygonum multiflorum is well-known as “Heshouwu” in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees. Objective: To research the anti-inflammatory activities of components from P. multiflorum. Materials and Methods: The compounds were isolated by a combination of silica gel and YMC R-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-nuclear magnetic resonance, and mass spectrometry). The anti-inflammatory activities of the isolated compounds 1−15 were evaluated by luciferase reporter gene assays. Results: Fifteen compounds (1–15) were isolated from the roots of P. multiflorum. Compounds 1−5 and 14−15 significantly inhibited tumor necrosis factor-α-induced nuclear factor kappa B-luciferase activity, with IC50 values of 24.16–37.56 µM. Compounds 1−5 also greatly enhanced peroxisome proliferator-activated receptors transcriptional activity with EC50 values of 18.26−31.45 μM. Conclusion: The anthraquinone derivatives were the active components from the roots of P. multiflorum as an inhibitor on inflammation-related factors in human hepatoma cells. Therefore, we suggest that the roots of P. multiflorum can be used to treat natural inflammatory diseases.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Sun, Y. N., Li, W., Song, S. B., Yan, X. T., Yang, S. Y., & Kim, Y. H. (2016). Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum. Pharmacognosy Magazine, 12(45), 31–5. https://doi.org/10.4103/0973-1296.176019