Comparation of Hypolipidemic and Antioxidant Effects of Aqueous and Ethanol Extracts of Crataegus pinnatifida Fruit in High‑Fat Emulsion‑Induced Hyperlipidemia Rats

ABSTRACT

Background: Hawthorn (Crataegus pinnatifida) is a Chinese medicinal plant traditionally used in the treatment of hyperlipidemia. Recently, studies indicated free radical scavenging was one of the major pathways to alleviate hyperlipidemia. Moreover, hawthorn fruit is a rich source of phenols, which quench free radical and attenuate hyperlipidemia. However, the phenols vary with processing methods, especially solvent type. Objective: Our aim was to compare hypolipidemic and antioxidant effects of aqueous and ethanol extracts of hawthorn fruit in hyperlipidemia rats. Materials and Methods: After a 4‑week treatment of high‑fat emulsion, lipid profile levels and antioxidant levels of two extracts were determined using commercial analysis. Total phenols content in the extract of hawthorn fruit was determined colorimetrically by the Folin–Ciocalteu method. Results: Both ethanol and aqueous extracts of hawthorn fruit possessed hypolipidemic and antioxidant activities. Simultaneously, stronger activities were observed in ethanol extract. Besides, total phenols content in ethanol extract from the same quality of hawthorn fruit was 3.9 times more than that in aqueous extract. Conclusion: The obvious difference of hypolipidemic and antioxidant effects between ethanol extract and aqueous extract of hawthorn fruit was probably due to the presence of total phenols content, under the influence of extraction solvent.

KEYWORDS

• Antioxidant activity
• Crataegus pinnatifida fruit
• hypolipidemic effect
• total phenols content

Showing references and in-text citations exactly as published.

• DOI10.4103/0973-1296.176049Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 12, ISSUE 45An Efficient High‑performance Liquid Chromatography Combined with Electrospray Ionization Tandem Mass Spectrometry Method to Elaborate the Changes of Components Between the Raw and Processed Radix Aconitum kusnezoffiiBeibei Wang, Jiaojiao Ji, Shuang Zhao, Jie Dong, Peng Tan, Shengsang Na, Yonggang Liu · pp. 4–8Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 45Optimization of Ultrasound‑assisted Extraction of Phenolic Compounds from Myrcia amazonica DC. (Myrtaceae) LeavesMariana Cristina de Morais Rodrigues, Leonardo Luiz Borges, Frederico Severino Martins, Rosa Helena V. Mourão · pp. 9–12Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 45Determination of Ruscogenin in Ophiopogonis Radix by High‑performance Liquid Chromatography‑evaporative Light Scattering Detector Coupled with Hierarchical Clustering AnalysisChun-Hua Liu, Ming Li, Ya-Qian Feng, Yuan-Jia Hu, Bo-Yang Yu, Jin Qi · pp. 13–20Original ArticleSame type: Article
• Article · VOLUME 12, ISSUE 45Luffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW‑480) in the Caspase‑dependent Manner and Through a Mitochondrial Apoptosis PathwayLi‑Hua Shang, Yan Yu, De‑Hai Che, Bo Pan, Shi Jin, Xiao‑Long Zou · pp. 25–30Original ArticleSame type: Article