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    Nanostructured Lipid Carriers Loaded with Baicalin: An Efficient Carrier for Enhanced Antidiabetic Effects

    Feng Shi1, Zheng Wei2, Yingying Zhao1, Ximing Xu1★★ Corresponding author

    1. 1Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China.
    2. 2Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou, PR, China.

    CORRESPONDENCE

    Ximing Xu

    Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, China.

    xmxu@ujs.edu.cn

    Received: 29-07-2015; Revised: 08-09-2015.

    Volume 12, Issue 47 · pp. 198–202 · PUBLISHED 14 July 2016 · DOI: 10.4103/0973-1296.186347

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Context: Recent studies have demonstrated that baicalin has antihyperglycemic effects by inhibiting lipid peroxidation. Baicalin is low hydrophilic and poorly absorbed after oral administration. Thus, a suitable formulation is highly desired to overcome the disadvantages of baicalin. Objective: The objective of this work was to prepare baicalin‑loaded nanostructured lipid carriers (B‑NLCs) for enhanced antidiabetic effects. Materials and Methods: B‑NLCs were prepared by high‑pressure homogenization method using Precirol as the solid lipid and Miglyol as the liquid lipid. The properties of the NLCs, such as particle size, zeta potential (ZP), and drug encapsulation efficiency ( EE), were investigated. The morphology of NLCs was observed by transmission electron microscopy. In addition, drug release and antidiabetic activity were also studied. Results: The results revealed that B‑NLCs particles were uniformly in the nanosize range and of spherical morphology with a mean size of 92 ± 3.1 nm, a ZP of −31.35 ± 3.08 mV, and an EE of 85.29 ± 3.42%. Baicalin was released from NLCs in a sustained manner. In addition, B‑NLCs showed a significantly higher antidiabetic efficacy compared with baicalin. Conclusion: B‑NLCs described in this study are well‑suited for the delivery of baicalin.

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      Shi, F., Wei, Z., Zhao, Y., & Xu, X. (2016). Nanostructured Lipid Carriers Loaded with Baicalin: An Efficient Carrier for Enhanced Antidiabetic Effects. Pharmacognosy Magazine, 12(47), 198–202. https://doi.org/10.4103/0973-1296.186347