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    Article

    Antiprotozoal Constituents from Annona cherimola Miller, a Plant Used in Mexican Traditional Medicine for the Treatment of Diarrhea and Dysentery

    Fernando Calzada1★, Jose Correa-Basurto2, Elizabeth Barbosa3, David Mendez-Luna4, Lilian Yepez-Mulia4★ Corresponding author

    1. 1Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades-2 piso CORCE Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc 330, Col. Doctores, D. F, México.
    2. 2Sección de Graduados y Departamento de Bioquímica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y DíazMirón, D. F, México.
    3. 3Sección de Graduados, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luís y DíazMirón, D. F, México.
    4. 4Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría. Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc 330, Col. Doctores, D. F, México.

    CORRESPONDENCE

    Fernando Calzada

    Unidad de Investigación Médica en Farmacología, UMAE Hospital de Especialidades-2 piso CORCE Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtemoc 330, Col. Doctores, D. F, México.

    fercalber10@gmail.com

    Received: 12-01-2016; Revised: 02-10-2016; Accepted: 02-10-2016.

    Volume 13, Issue 49 · pp. 148–52 · PUBLISHED 6 January 2017 · DOI: 10.4103/0973-1296.197636

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Annona cherimola Miller (Annonaceae) is a medicinal plant frequently recommended in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery. Objective: This work was undertaken to obtain information that support the traditional use of A. cherimola, on pharmacological basis using in vitro and computational experiments. Material and Methods: Bioassay-guided fractionation of the ethanol extract of the leaves of A. cherimola afforded five phenolic compounds: caffeic acid, quercetin, kaempferol, nicotinflorin, and rutin. Results: The in vitro antiprotozoal assay showed that kaempferol was the most potent antiamoebic and antigiardial compound with IC50 values of 7.9 μg/mL for Entamoeba histolytica and 8.7 μg/mL for Giardia lamblia. Computational molecular docking study showed that kaempferol interacted in a region different than metronidazole in the enzyme pyruvate: ferredoxin oxidoreductase (PFOR). Conclusion: Considering that PFOR is a target of metronidazole; kaempferol may be a lead compound for the development of novel antiprotozoal agent. Also, these findings give support to the use of A. cherimola in the traditional medicine from México for the treatment of diarrhea and dysentery.

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      Calzada, F., Correa-Basurto, J., Barbosa, E., Mendez-Luna, D., & Yepez-Mulia, L. (2017). Antiprotozoal Constituents from Annona cherimola Miller, a Plant Used in Mexican Traditional Medicine for the Treatment of Diarrhea and Dysentery. Pharmacognosy Magazine, 13(49), 148–52. https://doi.org/10.4103/0973-1296.197636