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    Effect of Naringenin (A naturally occurring flavanone) Against Pilocarpine-induced Status Epilepticus and Oxidative Stress in Mice

    Sheeba Shakeel1, Muneeb U. Rehman2, Nahida Tabassum3★, Umar Amin3, Manzoor ur Rahman Mir3★ Corresponding author

    1. 1Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India.
    2. 2Molecular Biology Laboratory, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sheri Kashmir University of Agricultural Science and Technology-Kashmir (SKUAST-K), Srinagar, Jammu and Kashmir, India.
    3. 3Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, Sheri Kashmir University of Agricultural Science and Technology-Kashmir (SKUAST-K), Srinagar, Jammu and Kashmir, India.

    CORRESPONDENCE

    Nahida Tabassum

    Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, Sheri Kashmir University of Agricultural Science and Technology-Kashmir (SKUAST-K), Srinagar, Jammu and Kashmir, India.

    sheebashakeel2@yahoo.com

    Received: 18-08-2016; Revised: 19-09-2016; Accepted: 07-04-2017.

    Volume 13, Issue 49s · pp. 154–60 · PUBLISHED 7 April 2017 · DOI: 10.4103/0973-1296.203977

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Epilepsy is a disorder of the central nervous system characterized by recurrent seizures. It is a very common disease in which approximately 30% of patients do not respond favourably to treatment with anticonvulsants. Oxidative stress is associated with neuronal damage arising from epileptic seizures. The present study investigated the effects of naringenin in pilocarpine-induced epilepsy in mice. Naringenin, one of the most frequently occurring flavanone in citrus fruits, was evaluated for its shielding effect against the pilocarpine induced behavioural, oxidative and histopathological alterations in rodent model of epilepsy. Methodology: Epilepsy was induced by giving pilocarpine (300mg/kg) and sodium valproate (300mg/kg) was given as standard anti-epileptic drug Pilocarpine was administered (300 mg /kg body weight) intraperitoneally to the mice on 15th day while naringenin was administered orally (20 and 40 mg/kg body weight) for 15 days prior to administration of pilocarpine. Results: The intraperitoneal administration of pilocarpine enhanced lipid peroxidation, caused reduction in antioxidant enzymes, viz., catalase, superoxide dismutase and glutathione reductase. Treatment of mice orally with naringenin (20 mg/kg body weight and 40 mg/kg body weight) resulted in a significant decrease in lipid peroxidation. There was significant recovery of glutathione content and all the antioxidant enzymes studied. Also in case of behavioural parameters studied, naringenin showed decrease in seizure severity. All these changes were supported by histological observations, which revealed excellent improvement in neuronal damage. Conclusion: The higher dose of naringenin was more potent in our study and was comparable to the standard drug (sodium valproate) in effectiveness.

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      Shakeel, S., Rehman, M. U., Tabassum, N., Amin, U., & Mir, M. U. R. (2017). Effect of Naringenin (A naturally occurring flavanone) Against Pilocarpine-induced Status Epilepticus and Oxidative Stress in Mice. Pharmacognosy Magazine, 13(49s), 154–60. https://doi.org/10.4103/0973-1296.203977