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    Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats

    Ganjikunta Venkata Subbaiah1, Korivi Mallikarjuna2, Bhasha Shanmugam1, Sahukari Ravi1, Patan Usnan Taj1, Kesireddy Sathyavelu Reddy1★★ Corresponding author

    1. 1Division of Molecular Biology and Ethnopharmacology, Department of Zoology, Sri Venkateswara University, Tirupati, India.
    2. 2Institute of Nutrition (16F), China Medical University, Taichung, Taiwan.

    CORRESPONDENCE

    Kesireddy Sathyavelu Reddy

    Division of Molecular Biology and Ethnopharmacology, Department of Zoology, Sri Venkateswara University, Tirupati, India.

    ksreddy2008@hotmail.com

    Received: 05-01-2016; Revised: 08-02-2016; Accepted: 08-02-2016.

    Volume 13, Issue 49s · pp. 69–75 · PUBLISHED 7 April 2017 · DOI: 10.4103/0973-1296.203891

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Alcohol-induced hyperlipidemia is positively correlated with cardiovascular diseases. Several herbal extracts have been reported to protect the cardiac injury and suppress the hyperlipidemia. However, the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage remains unclear. Objective: This study investigated the cardio-protective properties of ginger ethanolic extract (Gt) against alcohol-induced myocardial damage, and further distinguished the association between hyperlipidemia and occurrence of myocardial damage in rats. Materials and Methods: Twenty four Wistar male albino rats (250 ± 20 g) were divided into four groups including, Normal control (NC) (0.9% NaCl), Ginger treated (Gt) (200 mg/Kg b.w.), Alcohol treated (At) (20% of 6g/kg b.w. alcohol), and Alcohol along with Ginger treatment (At+Gt). In this study, lipid profiles such as fatty acids, triglycerides, total cholesterol, phospholipids, low density lipoprotein and high density lipoproteins, and cardiac biomarkers, including LDH, AST, CK-MB, cTn-T and cTn-I were examined in rats. Furthermore, histopathological studies were also conducted. Results: We found that alcohol-induced myocardial damage was associated with increased lipid profile except high density lipoprotein in alcohol treated (20%, 6g/kg b.w.) rats compared with control. Ginger treatment significantly reduced the alcohol-induced lipid profiles except high density lipoproteins. Furthermore, elevated cardiac biomarkers activity with alcohol intoxication was substantially suppressed by ginger treatment. In addition, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage. Conclusion: Our results concluded that ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers.

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      Subbaiah, G. V., Mallikarjuna, K., Shanmugam, B., Ravi, S., Taj, P. U., & Reddy, K. S. (2017). Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats. Pharmacognosy Magazine, 13(49s), 69–75. https://doi.org/10.4103/0973-1296.203891