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    Mechanism of Fructus Aurantii Flavonoids Promoting Gastrointestinal Motility: From Organic and Inorganic Endogenous Substances Combination Point of View

    Shuai Wang1★, Yong‑Rui Bao1★, Tian‑Jiao Li2,3,4,5, Ting Yu2, Xin Chang2, Guan‑Lin Yang2, Xian‑Sheng Meng2,3,4,5★★ Corresponding author

    1. 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, China.
    2. 2Component Medicine Engineering Research Center of Liaoning Province, China.
    3. 3Liaoning Province Modern Chinese Medicine Research Engineering Laboratory, China.
    4. 4Liaoning University of Traditional Chinese Medicine‑Agilent Technologies Modern TCM and Multi‑Omics Research Collaboration Lab, Dalian 116600, China.

    CORRESPONDENCE

    Shuai Wang

    School of Pharmacy, Liaoning University of Traditional Chinese Medicine, China.

    mxsvvv@163.com

    Received: 05-04-2016; Revised: 17-06-2016.

    Volume 13, Issue 51 · pp. 372–377 · PUBLISHED 19 July 2017 · DOI: 10.4103/pm.pm_179_16

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Fructus Aurantii (FA) derived from the dried, and unripe fruit of Citrus aurantium L. is one of the commonly used traditional Chinese medicines to treat gastrointestinal motility dysfunction diseases. According to the literature research, FA flavonoids (FAF) are important active ingredients of FA promoting gastrointestinal motility, but the exact material basis and mechanism of action are still not very clear. Objective: This experiment was designed to illustrate the material basis of FAF promoting gastrointestinal motility and explore the mechanism of action from an organic and inorganic combination point of view. Materials and Methods: In this experiment, high‑performance liquid chromatography (HPLC) method was used to analyze the composition and content of FAF. Based on the prominent prokinetic effect of FAF on mice, the mechanism of action was speculated through a combination of HPLC coupled with quadrupole time‑of‑flight mass spectrometry (HPLC‑QTOF‑MS) and inductively coupled plasma mass spectrometry (ICP‑MS). Results: With the method of HPLC, ten dominating components of FAF including neoeriocitrin, narirutin, rhoifolin, naringin, hesperidin, neohesperidin, neoponcirin, naringenin, hesperetin, and nobiletin accounting for more than 86% of FAF were identified. Combined HPLC‑QTOF‑MS with ICP‑MS, the endogenous substances with difference in the blood of mice were analyzed, in which 4‑dimethylallyltryptophan, corticosterone, phytosphingosine, sphinganine, LysoPC (20:4(5Z, 8Z, 11Z, 14Z)), LysoPC(18:2 (9Z, 12Z)), and Ca2+, Mg2+, Zn2+ metal ions had significant changes, involving tryptophan metabolism, corticosterone metabolism, sphingolipid metabolism, and other pathways. Conclusion: The results preliminarily elaborated the mechanism of FAF promoting gastrointestinal motility from an organic and inorganic point of view, which provide valuable information for researching and developing new multi‑component Chinese medicine curing gastrointestinal underpower associated diseases.

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      Wang, S., Bao, Y., Li, T., Yu, T., Chang, X., Yang, G., & Meng, X. (2017). Mechanism of Fructus Aurantii Flavonoids Promoting Gastrointestinal Motility: From Organic and Inorganic Endogenous Substances Combination Point of View. Pharmacognosy Magazine, 13(51), 372–377. https://doi.org/10.4103/pm.pm_179_16