Characterization of Nano Bamboo Charcoal Drug Delivery System for Eucommia ulmoides Extract and Its Anticancer Effect In vitro
Zhaoyan Zeng2, Xiangzhou Li2,3★, Sheng Zhang2, Dan Huang4★ Corresponding author
- 1Department of Chemical Engineering, College of Materials Science and Engineering, Central South University of Forestry and Technology, China.
- 2State Key Laboratory of Ecological Applied Technology in Forest Area of South China, Changsha 410004, China.
- 3State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (Incubation), Hunan University of Chinese Medicine, Changsha 410208, China.
CORRESPONDENCE
Xiangzhou Li
State Key Laboratory of Ecological Applied Technology in Forest Area of South China, Changsha 410004, China.
Received: 27-05-2016; Revised: 11-07-2016.
Volume 13, Issue 51 · pp. 498–503 · PUBLISHED 19 July 2017 · DOI: 10.4103/pm.pm_256_16
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ABSTRACT
Background: Nano bamboo charcoal is being widely used as sustained release carrier for chemicals for its high specific surface area, sound biocompatibility, and nontoxicity; however, there have been no reports on nano bamboo charcoal as sustained release carrier for traditional Chinese medicine (TCM). Objective: To study the effect of nano bamboo charcoal in absorbing and sustained releasing Eucommia ulmoides extract (EUE) and to verify the in vitro anticancer effect of the sustained release liquid, so as to provide a theoretical basis for the development and utilization of nano bamboo charcoal as TCM sustained-release preparation. Materials and Methods: The adsorption capacity for the nano bamboo charcoal on EUE was measured by Langmuir model, and the release experiment was carried out under intestinal fluid condition. Characteristic changes for the nano bamboo charcoal nano-drug delivery system with and without adsorption of E. ulmoides were evaluated by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and specific surface area. In addition, the anticancer effect from this novel bamboo charcoal E. ulmoides delivery system was evaluated against a human colon cancer cell line (HCT116). Results: It was found that nano bamboo charcoal exhibits good adsorption capacity (up to 462.96 mg/g at 37°C). The cumulative release rate for EUE from this nano bamboo charcoal delivery system was 70.67%, and specific surface area for the nano bamboo charcoal decreased from 820.32 m2/g to 443.80 m2/g after EUE was loaded. An in vitro anticancer study showed that the inhibition rate for E. ulmoides against HCT116 cancer cells was 23.07%, for this novel bamboo charcoal nano-drug delivery system. Conclusion: This study provides a novel strategy for the delivery of traditional Chinese medicine using bamboo charcoal nano-drug delivery system.
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Zeng, Z., Li, X., Zhang, S., & Huang, D. (2017). Characterization of Nano Bamboo Charcoal Drug Delivery System for Eucommia ulmoides Extract and Its Anticancer Effect In vitro. Pharmacognosy Magazine, 13(51), 498–503. https://doi.org/10.4103/pm.pm_256_16