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    Cytotoxic, Antimitotic, and Antiproliferation Studies on Rasam: A South Indian Traditional Functional Food

    Agilandeswari Devarajan2,3★, M. K. Mohan Maruga Raja3★ Corresponding author

    1. 1Department of Pharmaceutics, Hillside College of Pharmacy and Research Centre, Bengaluru, Karnataka, India.
    2. 2Department of Pharmacy, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India.

    CORRESPONDENCE

    Agilandeswari Devarajan

    Department of Pharmacy, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India.

    agilandeswaridevarajan@gmail.com

    Received: 11-04-2017; Revised: 18-05-2017.

    Volume 13, Issue 51s · pp. S452–S457 · PUBLISHED 11 October 2017 · DOI: 10.4103/pm.pm_138_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Rasam is a traditional South Indian food, prepared using tamarind juice as a base, with a variety of spices. Rasam, with all its ingredients medicinally claimed for various ailments, is a functional food. Systematic consumption of traditional functional food provides an excellent preventive measure to ward off many diseases. Objective: To study rasam for cytotoxic, antimitotic, and antiproliferation potential beyond its culinary and nutritional effect. Materials and Methods: Brine shrimp lethality assay, onion root tip inhibition assay, and 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay in Calu‑6, HeLa, MCF‑7 cell lines for four stage‑wise samples in the preparation of rasam (RS1, RS2, RS3, and RS4) were studied. Results: RS4, the end product of rasam showed high lethality with an LC50 value of 38.7 µL/mL. It showed maximum antimitotic activity in a dose‑dependent manner compared to other samples with an IC50 value of 189.86 µL/mL. RS4 also showed an IC50 value of 350.22 and 410.15 µL/mL in MCF‑7 and Calu‑6 cell lines, respectively. Conclusion: From this study, we suggest that rasam is a classic example of traditional functional food and it can treat breast and lung cancer on chronic use.

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      Devarajan, A., & Raja, M. K. M. M. (2017). Cytotoxic, Antimitotic, and Antiproliferation Studies on Rasam: A South Indian Traditional Functional Food. Pharmacognosy Magazine, 13(51s), S452–S457. https://doi.org/10.4103/pm.pm_138_17