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    Article

    Anti‑inflammatory Effects of Brassica oleracea Var. capitata L. (Cabbage) Methanol Extract in Mice with Contact Dermatitis

    Youjung Lee1★, Seoyoung Kim1★, Beodeul Yang1, Chiyeon Lim2, Jung‑Hoon Kim1, Hyungwoo Kim1★, Suin Cho1★ Corresponding author

    1. 1Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan.
    2. 2Department of Medicine, College of Medicine, Dongguk University, Seoul, South Korea.

    CORRESPONDENCE

    Youjung Lee

    Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan.

    kronos7@pusan.ac.kr

    Received: 20-04-2017; Revised: 17-05-2017.

    Volume 14, Issue 54 · pp. 174–179 · PUBLISHED 10 April 2018 · DOI: 10.4103/pm.pm_152_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Cabbage, Brassica oleracea var. capitata L., is one of the most common vegetables in the world. Because of its high levels of flavonoids and anthocyanins, cabbage has long been used as a herbal medicine. The antioxidant and anti‑inflammatory properties of cabbage were also recently been reported. Objective: This study was designed to investigate the anti‑inflammatory effects of cabbage in mice with contact dermatitis (CD). Materials and Methods: We investigated the effects of methanol extract of B. oleracea var. capitata L. (MEBO) on ear swelling, erythema, and histopathological changes in CD mice. Moreover, the effects on cytokine production and the spleen/body weight ratio were investigated. Results: Topical treatment with MEBO inhibited ear swelling and erythema significantly. MEBO also significantly inhibited epidermal hyperplasia and infiltration of immune cells. Furthermore, the levels of tumor necrosis factor‑alpha, interferon‑gamma, interleukin‑6, and monocyte chemotactic protein‑1 in inflamed tissues were effectively lowered by MEBO. Finally, MEBO did not affect body weight gain or spleen body weight ratio. Conclusions: These results indicate that cabbage can be used for the treatment of skin inflammation and that its anti‑inflammatory activity is closely related to the inhibition of Th1 skewing reactions.

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      Lee, Y., Kim, S., Yang, B., Lim, C., Kim, J., Kim, H., & Cho, S. (2018). Anti‑inflammatory Effects of Brassica oleracea Var. capitata L. (Cabbage) Methanol Extract in Mice with Contact Dermatitis. Pharmacognosy Magazine, 14(54), 174–179. https://doi.org/10.4103/pm.pm_152_17